Liver Transplantation in the Treatment of Unresectable Hepatocellular Carcinoma in the Absence of Liver Cirrhosis
https://doi.org/10.22416/1382-4376-2018-28-4-76-83
Abstract
Aim. The aim of the study is to determine the effectiveness of liver transplantation (LT) in the treatment of unresectable hepatocellular carcinoma (HCC) occurred in normal liver.
Material and methods. 6 patients with unresectable HCC underwent orthotopic liver transplantation (OLT). The long-term OLT results were compared with survival results of liver resection in patients with late stage HCC.
Results. Hepatocellular carcinoma is one of the most common types of cancer, which occurs mainly in patients with liver cirrhosis and chronic viral hepatitis. Only about 10 % of HCC develops in non-cirrhotic liver among young and somatically healthy patients. 1-, 3-, 5-year recurrence-free and overall survival in LT group was significantly better than in the control group.
Conclusion. LT is indicated for patients with unresectable HCC in non-cirrhotic liver and its extrahepatic localization. A large tumor size and macrovascular invasion should not be a contraindication for LT in such patients.
About the Authors
O. D. Olisov
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Cand. Sci. (Med.), Senior Researcher of the Department of Liver Transplantation
Russian Federation
Cand. Sci. (Med.), Senior Researcher of the Department of Liver Transplantation
M. S. Novruzbekov
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Cand. Sci. (Med.), Head of the Department of Liver Transplantation
Russian Federation
Cand. Sci. (Med.), Head of the Department of Liver Transplantation
I. E. Galankina
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Dr. Sci. (Med.), Professor, Head of the Department of Pathological Anatomy
Russian Federation
Dr. Sci. (Med.), Professor, Head of the Department of Pathological Anatomy
L. N. Zimina
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Dr. Sci. (Med.), Professor, Leading Researcher of the Department of Pathomorphology
Russian Federation
Dr. Sci. (Med.), Professor, Leading Researcher of the Department of Pathomorphology
V. A. Gulyaev
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Dr. Sci. (Med.), Leading Researcher of the Department of kidney and pancreas transplantation
Russian Federation
Dr. Sci. (Med.), Leading Researcher of the Department of kidney and pancreas transplantation
L. V. Donova
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Cand. Sci. (Med.), Senior Researcher of Department of Liver Transplantation
Russian Federation
Cand. Sci. (Med.), Senior Researcher of Department of Liver Transplantation
M. Sh. Khubutiya
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Dr. Sci. (Med.), Professor, RAS Academician, President
Russian Federation
Dr. Sci. (Med.), Professor, RAS Academician, President
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Review
For citations:
Olisov O.D., Novruzbekov M.S., Galankina I.E., Zimina L.N., Gulyaev V.A., Donova L.V., Khubutiya M.Sh. Liver Transplantation in the Treatment of Unresectable Hepatocellular Carcinoma in the Absence of Liver Cirrhosis. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2018;28(4):76-83. (In Russ.) https://doi.org/10.22416/1382-4376-2018-28-4-76-83
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