Morphological diagnostic criteria of autoimmune gastritis
https://doi.org/10.22416/1382-4376-2016-5-13-20
Abstract
Aim of investigation. To specify morphological features of autoimmune gastritis (AIH) and to indicate options for morphological diagnosis of this disease. Material and methods. The gastric biopsy specimens of 8 patients received at routine esophagogastroduodenoscopy (EGDS) were investigated. Biopsy specimens were processed by the standard technique. Serial sections were stained by hematoxyline and eosine, and immunehistochemical standing with anti-chromogranin A antibodies serum. Results. Morphological features of autoimmune gastritis, including cases with primary morphological diagnosis in contrast to the cases with primary serological diagnosis by anti-parietal cells antibodies are presented. The options of polyps or pseudopolyps detection at upper endoscopy are described which at morphological investigation correspond to sites of noninvolved mucosa of the body of stomach or hyperplastic foveolar layer. AIH can be characterized by metaplastic and non-metaplastic atrophy (intestinal and pseudo-pyloric metaplasia), pancreatic metaplasia, inflammatory infiltration with glandular epithelium destruction and T-lymphocyte emperipolesis, as well as by lipomatosis in lymphoid accumulations and neuroendocrine cell hyperplasia. Conclusion. Presented diagnostic features at autoimmune gastritis can be combined that is characteristic for this disease entity. In difficult cases at suspicion for AIH immunehistochemical staining for chromogranin A helps to diagnose neuroendocrine ECL cell hyperplasia, to specify its variant and to confirm the diagnosis.
About the Authors
Ye. A. Losik
Federal state educational government-financed institution of higher education «Sechenov First Moscow state medical university»
Russian Federation
Russian Federation
L. S. Selivanova
Federal state educational government-financed institution of higher education «Sechenov First Moscow state medical university»
Russian Federation
Russian Federation
T. V. Antonova
Federal state educational government-financed institution of higher education «Sechenov First Moscow state medical university»
Russian Federation
Russian Federation
T. L. Lapina
Federal state educational government-financed institution of higher education «Sechenov First Moscow state medical university»
Russian Federation
Russian Federation
Alexander S Tertychny
Federal state educational government-financed institution of higher education «Sechenov First Moscow state medical university»
Russian Federation
Russian Federation
V. T. Ivashkin
Federal state educational government-financed institution of higher education «Sechenov First Moscow state medical university»
Russian Federation
Russian Federation
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For citations:
Losik Ye.A., Selivanova L.S., Antonova T.V., Lapina T.L., Tertychny A.S., Ivashkin V.T. Morphological diagnostic criteria of autoimmune gastritis. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2016;26(5):13-20. (In Russ.) https://doi.org/10.22416/1382-4376-2016-5-13-20
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