Quantitative ultrasound rating of liver fibrosis in children with cystic fibrosis
Abstract
Aim of investigation. To determine potential of non-invasive ultrasound techniques of fibroelastometry (FEM) and Acoustic Structure Quantification (ASQ) at liver parenchyma assessment and fibrosis stage grading in children with cystic fibrosis (CF).
Material and methods. Overall 89 children in the age of 2 months to 18 years with pulmonary and intestinal form of cystic fibrosis were investigated. The course of CF in 64 patients was considered as moderate, in 25 — as severe. The diagnosis was established according to clinical and laboratoric investigation with analysis of past history data, DNA-diagnostics with assessment of genotype and positive sweat test.
Results. Evaluation of liver parenchyma with the help of traditional ultrasound investigation with assessment of blood flow in portal vessels and celiac trunk allows to determine degree of hepatic fibrosis severity and to reveal initial signs of portal hypertension. Application of ultrasound techniques of ASQ and FEM objectifies study results as alongside with the qualitative analysis of ultrasound echograms quantitative grading of liver parenchyma and fibrosis stage became possible.
Conclusions. ASQ in CF patients can be applied for early detection of fibrosis, follow-up of process development and rating of hepatoprotective treatment efficacy.
About the Authors
G. M. Dvoryakovskaya
Federal state-funded institution «Children health sciences centre», Russian academy of medical science
Russian Federation
Russian Federation
Dvoryakovskaya Galina M — MD, senior research associate, department of ultrasound diagnostics
119991, Moscow, Lomonosovsky prospekt, 2, bld 1
O. I. Simonova
Federal state-funded institution «Children health sciences centre», Russian academy of medical science
Russian Federation
Russian Federation
Simonova Olga I – MD, PhD, head of department of pulmonology and allergology
119991, Moscow, Lomonosovsky prospekt, 2, bld 1
S. A. Ivleva
Federal state-funded institution «Children health sciences centre», Russian academy of medical science
Russian Federation
Russian Federation
Ivleva Svetlana A – junior research associate, department of ultrasound diagnostics
119991, Moscow, Lomonosovsky prospekt, 2, bld 1
I. V. Dvoryakovsky
Federal state-funded institution «Children health sciences centre», Russian academy of medical science
Russian Federation
Russian Federation
A. N. Surkov
Federal state-funded institution «Children health sciences centre», Russian academy of medical science
Russian Federation
Russian Federation
M. O. Gorbunova
Federal state-funded institution «Children health sciences centre», Russian academy of medical science
Russian Federation
Russian Federation
I. E. Smirnov
Federal state-funded institution «Children health sciences centre», Russian academy of medical science
Russian Federation
Russian Federation
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Review
For citations:
Dvoryakovskaya G.M., Simonova O.I., Ivleva S.A., Dvoryakovsky I.V., Surkov A.N., Gorbunova M.O., Smirnov I.E. Quantitative ultrasound rating of liver fibrosis in children with cystic fibrosis. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2014;24(2):36-42. (In Russ.)
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