Potentials of intraesophageal рН-impedance measurement in GERD diagnostics
Abstract
The aim of review. To demonstrate potentials and advantage of new method of gastroesophageal reflux disease (GERD) diagnostics – esophageal рН-impedance measurement.
Key points. рН-impedance measurement of the esophagus allows to identify reflux episodes in the esophagus irrespective of refluxate рН. In contrast to traditional pH-metry the new method represents physical state of refluxate (gas, fluid, mixed contents), time of volume clearance to determine relation of observed symptoms to non-acidic refluxes. This promotes improvement of diagnostics and treatment of GERD.
Conclusion. Application of esophageal рН-impedance measurement allows to consider this method as the most exact and modern in diagnostics of GERD.
About the Authors
V. O. Kaybysheva
State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
O. A. Storonova
State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
A. S. Trukhmanov
State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
V. T. Ivashkin
State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
References
1. Гриневич В.Б. Мониторинг рН, желчи и импедансмониторинг в диагностике ГЭРБ // Эксперим. клин. гастроэнтерол. – 2004. – № 6. – С. 119–121.
2. Ивашкин В.Т., Маев И.В., Трухманов А.С. Пищевод Баррета. – М.: Шико, 2011. – С. 447–449.
3. Маев И.В., Вьючинова Е.С., Щекина М.И. Гастроэзофагеальная рефлюксная болезнь – болезнь XXI века // Лечащий врач. – 2004. – № 4. – С. 10–14.
4. Blom D., Mason R.J., Balaji N.S. et al. Esophageal bolus transport identified by simultaneous multichannel intraluminal impedance and manofluoroscopy // Gastroenterology. – 2001. – Vol. 120 – P. 103. [Abstract].
5. Bredenoord A.J., Tutuian R. et al. Technology Review: Esophageal Impedance Monitoring // Am. J. Gastroenterol. – 2007. – Vol. 102. – P. 187–194.
6. Bredenoord A.J., Weusten B.L., Sifrim D. et al. Aerophagia, gastric, and supragastric belching: a study using intraluminal electrical impedance monitoring // Gut. – 2004. – Vol. 53, N 11. – P. 1561–1565.
7. Fass J., Silny J., Braun J. et al. Measuring esophageal motility with a new intraluminal impedance device. First clinical results in reflux patients // Scand. J. Gastroenterol. – 1994. – Vol. 29. – P. 693–702.
8. Kahrilas P., Shaheen N., Vaezi M. American Gastroenterological Association Institute Technical Review on the Management of Gastroesophageal Reflux Disease // Gastroenterology. – 2008. – Vol. 135. – P. 1392–1413.
9. Mainie I., Tutuian R., Shay S. et al. Acid and nonacid reflux in patients with persistent symptoms despite acid suppressive therapy. A multicentre study using combined ambulatory impedance-pH monitoring // Gut. – 2006. doi:10.1136/gut.2005. 087668.
10. Shay S., Richter J. Direct comparison of impedance, manometry, and pH probe in detecting reflux before and after a meal // Dig. Dis. Sci. – 2005. – Vol. 50, N 9. – P. 1584–1590.
11. Shay S., Tutuian R., Sifrim D. et al. Twenty-four hour ambulatory simultaneous impedance and pH monitoring: a multicenter report of normal values from 60 healthy volunteers // Am. J. Gastroenterol. – 2004. – Vol. 99. – P. 1037–1043.
12. Sifrim D., Castell D., Dent J. et al. Gastroesophageal reflux monitoring: Review and consensus report on detection and definitions of acid, non-acid, and gas reflux // Gut. – 2004. – Vol. 53. – P. 1024–1031.
13. Sifrim D., Dupont L., Blondeau K. et al. Weakly acidic reflux in patients with chronic unexplained cough during 24-hour pressure, pH, and impedance monitoring // Gut. – 2005. – Vol. 54. – P. 449–454.
14. Sifrim D., Holloway R.H., Silny J. et al. Non-acid gastroesophageal reflux // Gastroenterology. – 2001. – Vol. 120 – P. 436. [Abstract].
15. Silny J. Intraluminal multiple electric impedance procedure for measurement of gastrointestinal motility // J. Gastrointest. Motil. – 1991. – Vol. 3. – P. 151–162.
16. Silny J., Knigge K.P., Fass J. et al. Verification of the intraluminal multiple electrical impedance measurement for recording of gastrointestinal motility // J. Gastrointest. Motil. – 1993. – Vol. 5. – P. 107–122.
17. Simren M., Silny J., Holloway R. et al. Relevance of ineffective oesophageal motility during oesophageal acid clearance // Gut. – 2003. – Vol. 52. – P. 784–790.
18. Tutuian R., Castell D. Clinical Application of ImpedanceManometry for Motility Testing and Impedance-pH for Reflux Monitoring // Clin. Gastroenterol. Hepatol. – 2005. – Vol. 2. – P. 230–236.
19. Tutuian R., Castell D. Rumination documented by using combined multichannel intraluminal impedance and manometry // Clin. Gastroenterol. Hepatol. – 2004. – Vol. 2, N 4. – P. 340–343.
20. Vela M.F., Camacho-Lobato L., Srinivasan R. et al. Simultaneous intraesophageal impedance and pH measurement of acid and nonacid gastroesophageal reflux: Effect of omeprazole // Gastroenterology. – 2001. – Vol. 120. – P. 1599–1606.
21. Zerbib F., des Varannes S.B., Roman S. et al. Normal values and day-to-day variability of 24-h ambulatory oesophageal impedance-pH monitoring in a BelgianFrench cohort of healthy subjects // Aliment. Pharmacol. Ther. – 2005. – Vol. 22. – P. 1011–1032.
22. Zerbib F., Roman S., Ropert A. et al. Esophageal pH-impedance monitoring and symptom analysis in GERD: a study in patients off and on therapy // Am. J. Gastroenterol. – 2006. – Vol. 101. – P. 1956–1963.
Review
For citations:
Kaybysheva V.O., Storonova O.A., Trukhmanov A.S., Ivashkin V.T. Potentials of intraesophageal рН-impedance measurement in GERD diagnostics. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2013;23(2):4-16. (In Russ.)
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