Morphological aspects of cell-based reconstruction of rectal mucosa at surgical treatment of familial adenomatosis coli
Abstract
Aim of investigation. To study pathogenic mechanisms and morphological signs of rectal mucosa reparation after rectal mucosectomy and application of cellbased biotechnologies at surgical treatment of familial adenomatosis coli (FAC).
Material and methods. The new method of FAC surgical treatment which provides preservation of part of the mucosa-deprived rectum is presented. For reconstruction of mucosa of the rectum cell-based allotransplantation was applied. Morphological mechanisms of mucosal reparation were investigated in 34 FAC patients (main and control groups).
Results. The reparation of mucosa in demucosated rectum at application of cell-based transplantation develops in shorter terms in comparison to control group. It is carried out by largeintestinal, smallintestinal types, by squamous cell differentiation and by combination of all types. At reparation cells with signs of stem cells take part.
Conclusions. Original method can be applied for treatment of FAC as it delays polyps and rectal cancer development for many years.
About the Authors
Ye. A. Kogan
Federal state-funded institution «Kulakov Federal Center on Obstetrics, Gynecology and Perinatology» Ministry of heathcare of the Russian Federation
Russian Federation
Russian Federation
D. V. Vyshegorodtsev
Federal state-funded institution «State Scientific Center of Coloproctology» Ministry of heathcare of the Russian Federation
Russian Federation
Russian Federation
N. M. Faizullina
Federal state-funded institution «Kulakov Federal Center on Obstetrics, Gynecology and Perinatology» Ministry of heathcare of the Russian Federation
Russian Federation
Russian Federation
T. A. Demura
Federal state-funded institution «Kulakov Federal Center on Obstetrics, Gynecology and Perinatology» Ministry of heathcare of the Russian Federation
Russian Federation
Russian Federation
A. M. Kuzminov
Federal state-funded institution «State Scientific Center of Coloproctology» Ministry of heathcare of the Russian Federation
Russian Federation
Russian Federation
Yu. A. Shelygin
Federal state-funded institution «State Scientific Center of Coloproctology» Ministry of heathcare of the Russian Federation
Russian Federation
Russian Federation
G. T. Sukhikh
Federal state-funded institution «Kulakov Federal Center on Obstetrics, Gynecology and Perinatology» Ministry of heathcare of the Russian Federation
Russian Federation
Russian Federation
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Review
For citations:
Kogan Ye.A., Vyshegorodtsev D.V., Faizullina N.M., Demura T.A., Kuzminov A.M., Shelygin Yu.A., Sukhikh G.T. Morphological aspects of cell-based reconstruction of rectal mucosa at surgical treatment of familial adenomatosis coli. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2013;23(6):73-79. (In Russ.)
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