Treatment of biliary cysts of the liver and polycystic liver disease: a surgical view
Abstract
Aim of the review. To present up-to-date management approach to biliary cysts of the liver and polycystosis.
Original positions. Opinions of surgeons differ in the issue of whom and when to operate, as well as in the choice of intervention procedure. At polycystosis, patients with the II type liver cysts (by J.Gigot classification) are exposed to treatment. At the presence of cysts of the III type, when the massive lesion of parenchyma takes place (>70%), there is no alternative for liver transplantation. At present there is no uniform medical approach in relation to diameter of cysts that results in application of various methods of treatment. Following variants are defined: 1) percutaneous puncture and drainage of cysts with injection of sclerosing agents; 2) laparoscopic erasion of free walls of cysts with impact on remaining epithelium; 3) erasion of cysts by laparotomic access. Laparoscopic resection of cysts is considered to be the optimal method that is low traumatic, with low frequency of relapses (0–4%) and minimum duration of hospital stay.
Conclusion. Only 5–10% of patients with not parasitic (biliary) cysts of the liver are subject to surgical treatment, the others should be observed either by gastroenterologist, or by surgeon of out-patient department.
About the Authors
M. P. KochievaRussian Federation
N. N. Bagmet
Russian Federation
A. G. Abdullayev
Russian Federation
O. G. Skipenko
Russian Federation
References
1. Вишневский В.А., Кубышкин В.А., Чжао А.В., Икрамов Р.З. Операции на печени: Руководство для хирургов. – М., 2003. – С. 76–79.
2. Гаврилин А.В., Вишневский В.А., Жаворонкова О.И. Непаразитарные кисты печени // Мед. газета. – 2008. – № 4. – С. 8–9.
3. Заривчацкий М.Ф., Пирожников О.Ю., Мугатаров И.Н., Гаврилов О.В. Принципы лечения непаразитарных кист печени // Вестн. хир. – 2006. – Т. 165, № 4. – С. 31–33.
4. Матевосян Р.В., Харнас С.С., Лотов А.Н. и др. Диагностика и выбор метода хирургического лечения при непаразитарных кистах печени // Хирургия. – 2002. – № 7. – С. 31–36.
5. Махов В.М., Ромасенко Л.В., Турко Т.В. Доброкачественные очаговые образования печени: возрастные психосоматические аспекты // Лечащий врач. – 2005. – № 2. – С. 24–28.
6. Нартайлаков М.А. Хирургия объемных образований и повреждений печени // Хирургия печени и желчных путей. – Ростов н/Д, 2007. – С. 188–189.
7. Руководство по хирургии печени и желчевыводящих путей / Под ред. А.Е. Борисова. – Том I. Хирургия печени. – СПб, 2003. – С. 223–257.
8. Руководство по хирургии печени и желчевыводящих путей / Под ред. А.Е. Борисова. – Том I. Хирургия печени. – СПб, 2003. – С. 488.
9. Старков Ю.Г., Шишин К.В., Вишневский В.А. и др. Лапароскопические операции при непаразитарных кистах печени // Анналы хир. гепатол. – 2007. – № 1. – C. 36–42.
10. Шишин К.В., Старков Ю.Г., Вишневский В.А. и др. Хирургическое лечение непаразитарных кист печени // Хирургия. – 2006. – № 10. – С. 62–66.
11. Abascal J., Moya M., Martin F. Infection of hepatic cysts in polycystic disease // World J. Surg. – 1984. – N 8. – P. 424–425.
12. Akkriviadis E.A., Steindel H., Ralls P. et al. Spontaneus rupture of nonparasitic cyst of the liver // Gastroenterology. – 1989. – N 97. – P. 213–215.
13. Ammori B.J., Jenkins B.L., Lim P.C. et al. Surgical strategy for cystic diseases of the liver in a western hepatobiliary center // World J. Surg. – 2002. – N 4. – P. 462–469.
14. Aoyagi T., Sasaki F., Okada T. et al. Rapidly enlarging solitary nonparasitic cyst of the liver in a child presenting as acute abdomen // Pediatr. Surg. Int. – 2007. – N 10. – P. 1007–1009.
15. Bean W.J., Rodan B.A. Hepatic cysts: treatment with alcohol // AJR Am. J. Roentgenol. – 1985. – Vol. 144. – P. 237–241.
16. Blonski W.C., Campbell M.S., Faust T., Metz D.C. Successful aspiration and ethanol sclerosis of a large, symptomatic, simple liver cyst: case presentation and review of the literature // World J. Gastroenterol. – 2006. – Vol. 12, N 18. – P. 2949–2954.
17. Brodsky K.S., McWilliams R.R., Amura C.R. et al. Liver cyst cytokines promote endothelial cell proliferation and development // ExP. Biol. Med. (Maywood). – 2009. – Vol. 234, N 10. – P. 1155–1165.
18. Buyse S., Asselah T., Vilgrain V. et al. Acute pulmonary embolism: a rare complication of a large non-parasitic hepatic cyst // Eur. J. Gastroenterol. Hepatol. – 2004. – Vol. 16, N 11. – P. 1241–1244.
19. Carswell K.A., Sagias F.G., Murgatroyd B. et al. Laparoscopic versus open left lateral segmentectomy // BMC Surg. – 2009. – N 9. – P. 14.
20. Cowles R.A., Mullholland M.W. Solitary hepatic cysts // J. Am. Coll. Surg. – 2000. – Vol. 101. – P. 311– 321.
21. D´Agata I.D., Jonas M.M., Perez-Atayde A.R., Guay-Woodford L.M. Combined cystic disease of the liver and kidney // Semin. Liver Dis. – 1994. – N 14. – P. 215– 228.
22. Ertem M., Uras C., Karahasanoglu T. et al. Laparoscopic approach to hepatic hydatid disease // Dig. Surg. – 1998. – N 15. – P. 333–336.
23. Fabiani P., Iannelli A., Chevallier P. et al. Long-term outcome after laparoscopic fenestration of symptomatic simple cysts of the liver // Br. J. Surg. – 2005. – Vol. 92, N 5 – P. 596–597.
24. Fabiani P., Mazza D., Toouli J. et al. Laparoscopic fenestration of symptomatic non-parasitic cysts of the liver // Br. J. Surg. – 1997. – Vol. 84, N 3 – P. 321–322.
25. Fiamingo P., Tedeschi U., Veroux M. et al. Laparoscopic treatment of simple hepatic cysts and polycystic liver disease // Surg. Endosc. – 2003. – N 17. – P. 623–626.
26. Gaines P.A., Sampson M.A. The prevalence and characterization of simple hepatic cysts by ultrasound examination // Br. J. Radiol. – 1989. – Vol. 62, N 736 – P. 335–337.
27. Gall T.M., Oniscu G.C., Madhavan K. et al. Surgical management and longterm follow-up of non-parasitic hepatic cysts // HPB (Oxford). – 2009. – Vol. 11, N 3. – P. 235–241.
28. Gamblin T.C., Holloway S.E., Heckman J.T., Geller D.A. Laparoscopic resection of benign hepatic cysts: a new standard // J. Am. Coll. Surg. – 2008. – Vol. 207, N 5. – P. 731–736.
29. Gao H., Wang Y., Wegierski T. et al. PRKCSH/80KH, the protein mutated in polycystic liver disease, protects polycystin-2/TRPP2 against HERP-mediated degradation // Hum. Mol. Genet. – 2009. – N 3. – P. 3.
30. Garcea G., Pattenden C.J., Stephenson J. et al. Nine-year single-center experience with nonparastic liver cysts: diagnosis and management // Dig. Dis. Sci. – 2007. – Vol. 52, N 1. – P. 185–191.
31. Gaviser D. Solitary nonparasitic cysts of the liver // Minn. Med. – 1953. – Vol. 36, N 8. – P. 831–836.
32. Gigot J.F., Hubert C., Banice R., Kendrick M.L. Laparoscopic management of benign liver diseases: where are we? // HPB (Oxford). – 2004. – Vol. 6, N 4. – P. 197–212.
33. Gigot J.F., Jadoul P., Que F. et al. Adult polycystic liver disease: is fenestration the most adequate operation for long-term management? // Ann. Surg. – 1997. – Vol. 225. – P. 286–294.
34. Giuliante F., D’Acapito F., Vellone M. et al. Risk for laparoscopic fenestration of liver cysts // Surg. Endosc. – 2003. – Vol. 17, N 11. – P. 1735–1738.
35. Hansen P., Bhoyrul S., Legha P. et al. Laparoscopic treatment of liver cysts // J. Gastrointest. Surg. – 1997. – Vol. 1, N 1. – P. 47–53.
36. Ikenaga N., Chijiiwa K., Otani K. et al. A case of peribiliary cyst presenting with obstructive jaundice // J. Gastrointest. Surg. – 2009. – Vol. 13, N 1. – P. 174–176.
37. Inayoshi A., Sawada T., Azuma K., Yagi Y. Three cases of nonparasitic liver cyst treated by intracystic instillation of acetic acid under ultrasonic guidance // Nippon Shokakibyo Gakkai Zasshi. – 1997. – Vol. 94, N9. – P. 627–631.
38. Ishii K., Yoshida H., Taniai N. et al. Infected hepatic cyst treated with percutaneous transhepatic drainage // J. Nippon Med. Sch. – 2009. – Vol. 76, N 3. – P. 160– 164.
39. Ishikawa H., Uchida S., Yokokura Y. et al. Nonparasitic solitary huge liver cysts causing intracystic hemorrhage or obstructive jaundice // J. Hepatobiliary Pancreat. Surg. – 2002. – Vol. 9, N 6. – P. 764–768.
40. Ito K., Taira K., Arii S. Intrahepatic bile duct dilatation with a liver cyst and hemangioma: report of a case // Surg. Today. – 2009. – Vol. 39, N 3. – P. 256–260.
41. Katkhouda N., Hurwitz M., Gugenheim J. et al. Laparoscopic management of benign solid and cystic lesions of the liver // Ann. Surg. – 1999. – Vol. 229, N 4. – P. 460–466.
42. Katkhouda N., Mavor E., Gugenheim J., Mouiel J. Laparoscopic management of benign cystic lesions of the liver // J. Hepatobiliary Pancreat. Surg. – 2000. – Vol. 7, N 2. – P. 212–217.
43. Konstadoulakis M.M., Gomatos I.P., Albanopoulos K. et al. Laparoscopic fenestration for the treatment of patients with severe adult polycystic liver disease // Am. J. Surg. – 2005. – Vol. 189, N 1. – P. 71–75.
44. Kornprat P., Cerwenka H., Bacher H. et al. Surgical therapy options in polycystic liver disease // Wien Klin. Wochenschr. – 2005. – Vol. 117, N 5–6. – P. 215– 258.
45. Kwok M.K., Lewin K.J. Massive hepatomegaly in adult polycystic liver disease // Am. J. Surg Pathol. – 1988. – Vol. 12, N 4. – P. 321–324.
46. Kwon A.H., Matsui Y., Inui H. et al. Laparoscopic treatment using an argon beam coagulator for nonparasitic liver cysts // Am. J. Surg. – 2003. – Vol. 185, N 3. – P. 273–277.
47. Larssen T.B., Rorvik J., Hoff S.R. et al. The occurrence of asymptomatic and symptomatic simple hepatic cysts. A prospective, hospital-based study // Clin. Radiol. – 2005. – Vol. 60, N 9. – P. 1026–1029.
48. Larssen T.B., Rørvik J., Horn A. et al. Biochemical and cytologic analysis of cystic contents in benign non-parasitic symptomatic hepatic cysts before and after ethanol sclerotherapy // Acta Radiol. – 2004. – Vol. 45, N 5. – P. 504–509.
49. Leung T.K., Lee C.M., Chen H.C. Fatal thrombotic complications of hepatic cystic compression of the inferior vena: a case report // World J. Gastroenterol. – 2005. – Vol. 11, N 11. – P. 1728–1729.
50. Lin T.Y., Chen C.C., Wang S.M. Treatment of nonparasitic cystic disease of the liver: a new approach to therapy with polycystic liver // Ann. Surg. – 1968. – Vol. 168. – P. 921–927.
51. Martin I.J., McKinley A.J., Currie E.J. et al. Tailoring the management of nonparasitic liver cysts // Ann. Surg. – 1998. – Vol. 228, N 2. – P. 167–172.
52. Mekeel K.L., Moss A.A., Reddy K.S. et al. Laparoscopic fenestration of giant hepatic cysts // Surg. Laparosc. Endosc. Percutan. Tech. – 2008. – Vol. 18, N 5. – P. 511–513.
53. Mimatsu K., Oida T., Kawasaki A. et al. Long-term outcome of laparoscopic deroofing for symptomatic nonparasitic liver cysts // Hepatogastroenterology. – 2009. – Vol. 56, N 91–92. – P. 850–853.
54. Miyamoto M., Oka M., Izumiya T. et al. Nonparasitic solitary giant hepatic cyst causing obstructive jaundice was successfully treated with monoethanolamine oleate // Intern. Med. – 2006. – Vol. 45, N 9. – P. 6621– 6625.
55. Mori T., Abe N., Sugiyama M., Atomi Y. Laparoscopic hepatobiliary and pancreatic surgery: an overview // J. Hepatobiliary Pancreat. Surg. – 2002. – Vol. 9, N 6. – P. 710–722.
56. Morino M., De Giuli M., Festa V., Garrone C. Laparoscopic management of symptomatic nonparasitic cysts of the liver. Indications and results // Ann. Surg. – 1994. – Vol. 219, N 2. – P. 157–164.
57. Nelson J., Davidson D., McKittrick J.E. Simple surgical treatment of nonparasitic hepatic cysts // Am. Surg. – 1992. – Vol. 58, N 12. – P. 755–757.
58. Neri V., Ambrosi A., Fersini A. et al. Laparoscopic treatment of biliary cysts: short- and medium-term results // HPB. – 2006. – N 8. – P. 306–310.
59. Oniscu G.C., Madhavan K., Parks R.W., Garden O.J. Surgical management and longterm follow-up of non-parasitic hepatic cysts // HPB (Oxford). – 2009. – Vol. 11, N 3. – P. 235–241.
60. Otani Y., Takayasu H., Ishimaru Y. et al. Secretion and expression of epithelial markers supports the biliary origin of solitary nonparasitic cyst of the liver in infancy // J. Pediatr. Surg. – 2005. – Vol. 40, N 12. – P. 27– 30.
61. Palanivelu C., Jani K., Malladi V. Laparoscopic management of benign nonparasitic hepatic cysts: A prospective nonrandomized study // South Med. J. – 2006. – Vol. 99, N 10. – P. 1063-1067.
62. Palanivelu C., Rangarajan M., Senthilkumar R., Madankumar M.V. Laparoscopic management of symptomatic multiple hepatic cysts: a combination of deroofing and radical excision // JSLS. – 2007. – Vol. 11, N 4. – P. 466–469.
63. Parenti R., Leone V., Del Buono G. et al. Obstructive jaundice caused by solitary nonparasitic cyst of the liver // Minerva Chir. – 1991. – Vol. 46, N 6. – P. 273– 277.
64. Pavlidis T.E. The role of laparoscopy in the management of segment VII nonparasitic liver cyst // J. Laparoendosc. Adv. Surg. Tech. – 2006. – Vol. 16, N 1. – P. 81.
65. Petri A., Höhn J., Makula E. et al. Experience with different methods of treatment of nonparasitic liver cysts // Langenbecks Arch. Surg. – 2002. – Vol. 387, N 5–6. – P. 229–233.
66. Plard L., Guedin P., Le Pennec V., Chiche L. Hepatic cysts: diagnosis and management // J. Chir. (Paris). – 2008. – Vol. 145, N 3. – P. 217–225.
67. Poggi G., Gatti C., Delmonte A. et al. Spontaneous rupture of non-parasitic hepatic cyst // Int. J. Clin. Pract. – 2006. – Vol. 60, N 1. – P. 99–103.
68. Poźniczek M., Wysocki A., Bobrzyński A. et al. Sclerosant therapy as first-line treatment for solitary liver cysts // Dig. Surg. – 2004. – Vol. 21, N 5–6. – P. 452–454.
69. Regev A., Reddy K.R., Berho M. et al. Large cystic lesions of the liver in adults: a 15-year experience in a tertiary center // J. Am. Coll. Surg. – 2001. – Vol. 193, N 1. – P. 36–45.
70. Robert T., Russel C. Write Pinson. Surgical management of polycystic liver disease // World J. Gastroenterol. – 2007. – Vol. 13, N 38. – P. 5052–5059.
71. Robinson T.N., Stiegmann G.V., Everson G.T. Laparoscopic palliation of polycystic liver disease // Surg. Endosc. – 2005. – Vol. 19, N 1. – P. 130–132.
72. Russell R.T., Pinson C.W. Surgical management of poly-cystic liver disease // World J. Gastroenterol. – 2007. – Vol. 13, N 38. – P. 5052–5059.
73. Saini S., Mueller P.R., Ferrucci J.T.Jr. et al. Percutaneous aspiration of hepatic cysts does not provide definitive therapy // AJR Am. J. Roentgenol. – 1983. – Vol. 141, N 3. – P. 559–560.
74. Salemis N.S., Georgoulis E., Gourgiotis S., Tsohataridis E. Spontaneous rupture of a giant non parasitic hepatic cyst presenting as an acute surgical abdomen // Ann. Hepatol. – 2007. – Vol. 6, N 3. – P. 190–193.
75. Sendt W., Weber T., Retschke S., Altendorf-Hofmann A. Symptomatic non-parasitic liver cysts: early and long-term results of surgical management // Zentralbl. Chir. – 2009. – Vol. 134, N 2. – P. 149–154.
76. Sheresta R., McKinley C., Russ P. et al. Postmenopausal estrogen therapy selectively stimulates hepatic enlargement in women with autosomal dominant disease // Hepatology. – 1997. – Vol. 26, N 5. – P. 1282–1286.
77. Szabó L.S., Takács I., Arkosy P. et al. Laparoscopic treatment of nonparasitic hepatic cysts // Surg Endosc. – 2006. – Vol. 20, N 4. – P. 595–597.
78. Takahashi G., Yoshida H., Mamada Y. et al. Intracystic hemorrhage of a large simple hepatic cyst // J. Nippon Med. Sch. – 2008. – Vol. 75, N 5. – P. 302–305.
79. Tan Y.M., Chung A., Mack P. et al. Role of fenestration and resection for symptomatic solitary liver cysts // ANZ J Surg. – 2005. – Vol. 75, N 7. – P. 577–580.
80. Telenti A., Torres V.E., Gross J.B.Jr. et al. Hepatic cyst infection in autosomal dominant polycystic kidney disease // Mayo Clin Proc. – 1990. – Vol. 65. – P. 933–942.
81. Tocchi A., Mazzoni G., Costa G. et al. Symptomatic nonparasitic hepatic cysts // JAMA. – 2002. – Vol. 137. – P. 154–158.
82. Tucker O.N., Smith J., Fenlon H.M., McEntee Giant solitary non-parasitic cyst of the liver // Ir. Med. Sci. – 2005. – Vol. 174, N 2. – P. 60–62.
83. Weber T., Sendt W., Scheele J. Laparoscopic unroofing of nonparasitic liver cysts within segments VII and VIII: technical considerations // J. Laparoendosc. Adv. Surg. Tech. A. – 2004. – Vol. 14, N 1. – P. 37–42.
84. Yamada T., Furukawa K., Yokoi K. et al. Liver cyst with biliary communication successfully treated with laparoscopic deroofing: a case report // J. Nippon Med. Sch. – 2009. – Vol. 76, N 2. – P. 103–108.
85. Yamaguchi M., Kuzume M., Matsumoto T. et al. Spontaneous rupture of a nonparasitic liver cyst complicated by intracystic hemorrhage // J. Gastroenterol. – 1999. – Vol. 34, N 5. – P. 645–648.
86. Yang C.F., Liang H.L., Pan H.B. et al. Single-session prolonged alcohol-retention sclerotherapy for large hepatic cysts // AJR Am. J. Roentgenol. – 2006. – Vol. 187, N 4. – P. 940–943.
87. Yoshida H., Onda M., Tajiry T. et al. Long-term results of multiple monocycline hydrochloride injections for the treatment of symptomatic solitary hepatic cyst // J. Gastroenterol. Hepatol. – 2003. – Vol. 18. – P. 595– 598.
88. Zacherl J., Scheuba C., Imhof M. et al. Long-term results after laparoscopic unroofing of solitary symptomatic congenital liver cysts // Surg. Endosc. – 2000. – Vol. 14, N 1. – P. 59–62.
89. Zerem E., Imamović G., Omerović S. Percutaneous treatment of symptomatic non-parasitic benign liver cysts: single-session alcohol sclerotherapy versus prolonged catheter drainage with negative pressure // Eur. Radiol. – 2008. – Vol. 18, N 2. – P. 400–406.
90. Zhang Y.L., Yuan L., Shen F., Wang Y. Hemorrhagic hepatic cysts mimicking biliary cystadenoma // World J. Gastroenterol. – 2009. – Vol. 15, N 36. – P. 4601– 4603.
Review
For citations:
Kochieva M.P., Bagmet N.N., Abdullayev A.G., Skipenko O.G. Treatment of biliary cysts of the liver and polycystic liver disease: a surgical view. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2010;20(1):30-37. (In Russ.)