A Case Series of Prostate Cancer Metastases to the Sigmoid Mesocolon in Patients with Colorectal Cancer

This article presents three rare clinical cases of prostate cancer metastasis to the mesosigmoid lymph nodes in patients with primary multiple prostate and sigmoid colon cancer. We were able to find descriptions of only three similar cases in international literature. In all cases, the source of metastasis was confirmed by immunohistochemistry: expression of prostate biomarkers and the absence of expression of intestinal adenocarcinoma markers were detected. Furthermore, we describe a case of the so-called “collision phenomenon” in one of the lymph nodes. The detection of prostate cancer metastases to the mesocolic region demonstrates the interconnection between the lymphatic collectors of the colon and the prostate gland. Therefore, it is important to conduct a thorough pathological examination of the surgical specimen, and in ambiguous cases, immunohistochemistry is indicated for accurate diagnosis and treatment planning. Further studies are needed to investigate the relationship between lymphatic drainage pathways from the prostate and distal colon.

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