Prognostic value of IL-6 in blood serum and cytochrome Р450 in liver tissue in patients with chronic hepatitis C
Abstract
Aim of investigation. To estimate relation of interleukin-6 (IL-6) level in blood serum of patients with chronic hepatitis C (CHC) with features of clinical course, degree of fibrosis and level of cytochrome Р450 expression in liver for prognosis assessment.
Stuff and methods. Overall 124 patients at different stages of CHC were investigated with assessment of IL-6 level in blood serum. In 36 patients cytochrome Р450 of isoform CYP2E1 gene expression was studied in liver tissue at biopsy samples.
Results. Patients with progression of liver fibrosis had high levels of IL-6 in blood serum and decrease of cytochrome Р450 gene expression in hepatocytes, that positively correlated to degree of liver fibrosis and rate of its progression.
Conclusion. According to multifactor discriminant analysis elevation of IL-6 in blood serum of CHC patients is independent factor of liver fibrosis progression as well as the age and renal disease.
About the Authors
Yu. V. KorotchayevaRussian Federation
L. M. Samokhodskaya
Russian Federation
A. I. Speransky
Russian Federation
L. V. Kozlovskaya
Russian Federation
N. B. Gordovskaya
Russian Federation
A. V. Pavlenko
Russian Federation
N. A. Mukhin
Russian Federation
V. A. Tkachuk
Russian Federation
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Review
For citations:
Korotchayeva Yu.V., Samokhodskaya L.M., Speransky A.I., Kozlovskaya L.V., Gordovskaya N.B., Pavlenko A.V., Mukhin N.A., Tkachuk V.A. Prognostic value of IL-6 in blood serum and cytochrome Р450 in liver tissue in patients with chronic hepatitis C. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2008;18(2):42-47. (In Russ.)
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