Возможное участие бактерий рода Helicobacter в патогенезе гепатобилиарных заболеваний

Цель обзора. Представить анализ данных литературы о возможном участии бактерий рода Helicobacter в патогенезе заболеваний гепатобилиарной системы.
Последние данные литературы. В ходе научных исследований, проведенных в последнее время, бактерии выявлены в желчи, тканях печени, слизистой оболочке желчного пузыря и желчных протоков, что свидетельствует о их способности колонизировать органы гепатобилиарной системы. На существование возможной связи бактерий рода Helicobacter с развитием хронического холецистита, желчнокаменной болезни, холангио-­ и гепатокарциномы указывают многочисленные исследования с использованием молекулярных, гистологических, микроскопических, бактериологических, иммунологических методов, опыты на биологических моделях. Расшифровка патогенетических механизмов с участием этих микроорганизмов открывает перспективу применения антигеликобактерной терапии для лечения и профилактики заболеваний гепатобилиарной системы.
Заключение. Накопленные сведения о роли H. pylori и других видов рода Helicobacter в развитии патологии печени, желчного пузыря и желчевыводящих путей позволяют сделать первоначальные выводы о их возможном участии в этих процессах. Несмотря на противоречивость мнений, это новое быстро развивающееся направление можно отнести к весьма перспективному и требующему продолжения исследований в данной области.

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