Possible involvement of Helicobacter spp. bacteria in pathogenesis of hepatobiliary diseases

The aim of review. To present analysis of literature data on possible participation of Helicobacter species in pathogenesis of diseases of hepatobiliary system.

Recent literature data. During recent studies, bacteria were revealed in bile, liver tissue, mucosa of the gallbladder and bile ducts that proves ability of Helicobacters to colonize hepatobiliary organs. Multiple investigations with application of molecular, histological, microscopic, bacteriological, immunologic methods, biological models experiments indicate the possible relation of Helicobacter spp. to development of chronic cholecystitis, cholelithiasis, cholangio- and hepatocarcinoma. Decoding of pathogenic mechanisms involving these microorganisms opens prospects for application of antihelicobacter therapy in treatment and prophylaxes of hepatobiliary diseases.

Conclusion. Cumulative data on the role of H. pylori and other species of Helicobacter genus in development of liver, gallbladder and biliary diseases allow to draw initial conclusions on their probable involvement in these processes. Despite equivocal opinions, this new rapidly educing trend may be rather perspective and require further studies in this area.

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