Comparison of invasive and non-invasive methods of Helicobacter pylori infection diagnostics in the stomach and oral cavity at patients with acid-related diseases
Abstract
Aim of investigation. To compare various methods of H. pylori detection in oral cavity at patients with acidrelated diseases.
Stuff and methods. 52 patients (36 women and 16 men) aged 18 to 65 years were investigated. All of them were distributed into 3 groups: 1st group – 16 patients with non-erosive gastroesophageal reflux disease and concomitant chronic active gastritis (CAG). 2nd group – 17 patients with grade A erosive esophagitis, CAG and duodenal peptic ulcer, 3rd group – 19 patients with reflux-esophagitis of a grade B (10), grade C (9) and gastroduodenitis. Clinical stomatological methods of investigation, morphology, cytology and biochemical methods of investigation of stomach mucosa (SM) and oral mucosa (OM) were applied.
Results. Clinical stomatological signs – erosion of enamel, hypersensitivity of teeth, hemorrhagic gingival diathesis, edema of oral mucosa, desquamation of epithelium, pain or burning sensation of the tongue, dryness in the mouth and lips, development of scales on labial mucosa (exfoliative cheilitis), angular stomatitis, aphthous stomatitis – were found in patients with acid-associated diseases and H. pylori infection. Data of morphological, cytological, biochemical and PCR studies of stomach mucosa have shown high level of H. pylori colonization at all patients. The same methods of investigation for oral cavity revealed presence of H. pylori markers in scrapings from root of the tongue, for the first time in mixed saliva.
Conclusion. Results of cytologic, histological methods, PCR -diagnostics were similar to those at application of rapid urease test which has been carried out for SM and OM that confirms high information value of this rapid test.
About the Authors
E. A. BazikyanRussian Federation
I. V. Mayev
Russian Federation
E. N. Nikolayeva
Russian Federation
G. I. Lukina
Russian Federation
Ye. V. Mukhina
Russian Federation
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Review
For citations:
Bazikyan E.A., Mayev I.V., Nikolayeva E.N., Lukina G.I., Mukhina Ye.V. Comparison of invasive and non-invasive methods of Helicobacter pylori infection diagnostics in the stomach and oral cavity at patients with acid-related diseases. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2008;18(4):32-37. (In Russ.)
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