Serum phospholipids, lipid peroxidation scores and anti-oxidative protection as additional non-invasive markers of chronic viral hepatitis C activity
Abstract
Aim of investigation. To study potential of application of serum phospholipids (PL), intensity of lipid peroxidation (LP) and total serum anti-oxidative capacity (TAC) parameters as non-invasive markers of disease activity at a chronic viral hepatitis C (CHC).
Materials and methods. Ninety patients with CHC were investigated, of them 32 were monitored at combined antiviral therapy (AVT). Level of PL in blood was determined by Trinder method, TAC of blood serum – by microtablet colorimetric method. Level of LP was estimated by malonic dialdehyde (MDA) using reaction with thiobarbituric acid. PL, MDA and TAC were investigated before and after treatment.
Results. Significant decrease of PL saturation of blood serum was detected at investigated patients, contents of MDA and level of TAC have been elevated. No relation of investigated parameters to AlAT activity was revealed, but negative correlation between PL level and histological activity index (HAI) and positive correlation between MDA and HAI, АОС and HAI were revealed. Investigated parameters did not depend on index of fibrosis. During the course of AVT blood MDA content and АОС activity were decreased. PL concentration has increased, however remained lower than at healthy controls. It was concluded, that serum PL, LP and anti-oxidative protection parameters can be used as non-invasive markers of inflammation activity. Low blood saturation of PL, and absence of normalization of their level at AVT give theoretical prerequisites for application of essential PL drugs as adjuvant therapy for CHC patients.
About the Authors
N. I. GeyvandovaRussian Federation
A. V. Yagoda
Russian Federation
D. A. Gudzovskaya
Russian Federation
I. V. Kostornaya
Russian Federation
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For citations:
Geyvandova N.I., Yagoda A.V., Gudzovskaya D.A., Kostornaya I.V. Serum phospholipids, lipid peroxidation scores and anti-oxidative protection as additional non-invasive markers of chronic viral hepatitis C activity. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2008;18(6):38-42. (In Russ.)
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