Clinical and genetic aspects of inflammatory bowel diseases
Abstract
Aim of investigation. To study clinical and epidemiologic features of inflammatory bowel diseases (IBD) and their relation to TNF-a, and СD14 genes polymorphism in Novosibirsk population.
Materials and methods. According to medical aid appealability and archival documents, data for 527 IBD patients were obtained: 375 had ulcerative colitis (UC), 277 – Crohn’s disease (CD) and 28 – «indeterminate» colitis. Clinical analysis was carried out by type and course of disease, localization and prevalence of process. In 120 patients (57 – with CD, 63 – with UC) frequency of TNF-a (–G308A) and СD14 (–С260Т) genes polymorphism was studied in comparison to population data.
Results. Clinical and epidemiologic characteristics of patients with IBD in Novosibirsk essentially do not differ from the scores obtained in other regions of Russia. Frequency of TNF-a gene –G308A polymorphism in city inhabitants with IBD, significantly differed from population data: genotype А/А at IBD was detected 4,7 times, and at CD – 7,7 times is more frequently, than in general population, A allele carriage was 1,7 and 2,2 times more frequent respectively. Frequency of CD14 gene –С260Т polymorphism at IBD also significantly differed from population: С/С genotype at IBD is revealed 1,8, and at UC – 2,2 times more frequently, than in general population, frequency of Т/Т genotype is 2,5 times higher at CD, than in general population.
Conclusion. Contribution of the revealed gene polymorphism to IBD predisposition at Novosibirsk inhabitants is quite high. Further studies are necessary.
About the Authors
Ye. Yu. ValuyskikhRussian Federation
I. O. Svetlova
Russian Federation
S. A. Kurilovich
Russian Federation
M. F. Osipenko
Russian Federation
V. N. Maximov
Russian Federation
M. I. Voyevoda
Russian Federation
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Review
For citations:
Valuyskikh Ye.Yu., Svetlova I.O., Kurilovich S.A., Osipenko M.F., Maximov V.N., Voyevoda M.I. Clinical and genetic aspects of inflammatory bowel diseases. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2008;18(6):68-74. (In Russ.)
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