Application of Fibrin Glue in the Treatment of Rectal Fistula
https://doi.org/10.22416/1382-4376-2019-29-1-31-35
Abstract
Aim: to summarize the literature data on the treatment of rectal fistula using fibrin glue.
Key findings: The prevalence of rectal fistula is about 9 cases per 100,000 population. Patients with rectal fistulas are frequently represented by the able-bodied middle-aged population group. The disease is extremely rarely observed in children and elderly people. Thus, this problem has a socially significant character. Fistula elimination is possible only by surgery, which is accompanied by the risk of fistula recurrence and the development of postoperative incontinence. In this regard, low-invasive techniques for the treatment of rectal fistulas, such as the use of fibrin glue, are being actively investigated.
Conclusion: The use of fibrin glue as a sphincter-preserving technique eliminates the development of postoperative anal failure, while new technologies and materials aim to reduce the risk of the disease recurrence.
About the Authors
Sergey A. FrolovRussian Federation
Dr. Sci. (Med.), Prof., Winner of the Prize of the Russian Federation Government in the Field of Science and Technology, Deputy director
123423, Moscow, Salyama Adilya str., 2.
Alexandr M. Kuzminov
Russian Federation
Dr. Sci. (Med.), Prof., Departmental Head, Department of General Coloproctology with a Group for Studying the Familial adenomatous Polyposis
123423, Moscow, Salyama Adilya str., 2.
Dmitry V. Vyshegorodtsev
Russian Federation
Cand. Sci. (Med.), Senior Researcher, Department of General Coloproctology with a Group for Studying the Familial adenomatous Polyposis
123423, Moscow, Salyama Adilya str., 2.
Vyacheslav Yu. Korolik
Russian Federation
Cand. Sci. (Med.), Researcher, Department of General Coloproctology with a Group for Studying the Familial Adenomatous Polyposis
123423, Moscow, Salyama Adilya str., 2.
Sharof T. Minbaev
Russian Federation
Cand. Sci. (Med.), Doctor, Department of General Coloproctology with a Group for Studying the Familial Adenomatous Polyposis
123423, Moscow, Salyama Adilya str., 2.
Ilya S. Bogormistrov
Russian Federation
Cand. Sci. (Med.), Doctor, Scientific-consulting clinic
123423, Moscow, Salyama Adilya str., 2.
Evgeny V. Kim
Russian Federation
Clinical Post-graduate Student, Department of Coloproctology
123423, Moscow, Salyama Adilya str., 2.
References
1. Abcarian H. Anorectal infection: Abscess-fistula. Clin Colon Rectal Surg. 2011;24(1):14–21.
2. Parks A.G., Gordon P.H., Hardcastle J.D. A classification of fistula-in-ano. Br J Surg. 1976;63(1):1–12.
3. Sainio P. Fistula in ano in a defined population: incidence and epidemiology of patients. Ann Chir Gynaecol. 1984;73:219–24.
4. Bleier J., Moloo H. Current management of cryptoglandular fistula-in-ano. World J Gastroenterol. 2011;17(28):3286–91.
5. Garcia-Aguilar J., Belmonte C., Wong W.D., Goldberg S.M., Madoff R.D. et al. Anal fistula surgery. Factors associated with recurrence and incontinence. Dis Colon Rectum. 1996;39:723–9.
6. Bergel S. Über Wirkungen des Fibrins. Deutsch Med Wochenschr. 1909;35:633–65.
7. Grey E.G. Fibrin as a hemostatic in cerebral surgery. Surg Gyn Obstet. 1915;21:452–4.
8. Harvey S.C. Fibrin paper as an hemostatic agent. Ann Surg. 1918;68:66–70.
9. Cronkite E.P., Lozner E.L., Deaver J.M. Use of thrombin and fibrinogen in skin grafting. JAMA. 1944;124:976–8.
10. Tidrick R.T., Warner E.D. Fibrin fixation of skin transplants. Surgery. 1944;15:90.
11. Matras H., Braun F., Lassman H., Ammerer H.P., Mamoli B. Plasma clot welding of nerves. J Maxillofac Surg. 1973;1:236–47.
12. Hjortrup A., Moesgaard F., Kjærgård J. Fibrin adhesive in the treatment of perineal fistulas. Dis Colon Rectum. 1991;34(9):752–4.
13. Venkatesh K.S., Ramanujam P. Fibrin glue application in the treatment of recurrent anorectal fistulas. Dis Colon Rectum. 1999;42(9):1136–9.
14. Hammond T.M., Grahn M.F., Lunniss P.J. Fibrin glue in the management of anal fistulae. Colorectal Dis. 2004;6(5):308–19.
15. Gugerell A., Schossleitner K., Wolbank S., Nürnberger S., Redl H., Gulle H. et al. High thrombin concentrations in fibrin sealants induce apoptosis in human keratinocytes. J Biomed Mater Res. Part A. 2012:100A:1239–47.
16. Singer M. et al. Treatment of fistulas-in-ano with fibrin sealant in combination with intra-adhesive antibiotics and/or surgical closure of the internal fistula opening. Dis Colon Rectum. 2005;48(4):799–808.
17. Lindsey I., Smilgin-Humphreys M.M., Cunningham C. et al. A randomized controlled trial of fibrin glue vs conventional treatment for anal fistula. Dis Colon Rectum. 2002;45:1608–15.
18. Cirocchi R., Santoro A., Trastulli S., Farinella E., di Rocco G. et al. Meta-analysis of fibrin glue versus surgery for treatment of fistula-in-ano. Ann Ital Chir. 2010;81:349–56.
19. Swinscoe M.T., Ventakasubramaniam A.K., Jayne D.G. Fibrin glue for fistula-in-ano: the evidence reviewed. Tech Coloproctol. 2005;9(2):89–94.
20. Lewis R., Lunniss P.J., Hammond T.M. Novel biological strategies in the management of anal fistula. Colorectal Dis. 2012;14(12):1445–55.
21. Frolov S.A., Kuzminov A.M., Korolik V.Yu., Bogormistrov I.S., Minbayev Sh.T., Chernozhukova M.O. The first experience of two-stage treatment of transsphincteric fistulas of rectum by means of fibrin sealant. Rus J Gastroenterol Hepatol Coloproctol. 2017;27(4):102–7 (In Rus.) DOI: 10.22416/1382-4376-2017-27-4-102-107
22. The first domestic surgical glue enters the market. International medical journal. 2016;3(20):64–6 (In Rus.) http://intergrupp-journal.ru/wp-content/uploads/2017/05/315.pdf
Review
For citations:
Frolov S.A., Kuzminov A.M., Vyshegorodtsev D.V., Korolik V.Yu., Minbaev Sh.T., Bogormistrov I.S., Kim E.V. Application of Fibrin Glue in the Treatment of Rectal Fistula. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2019;29(1):31-35. (In Russ.) https://doi.org/10.22416/1382-4376-2019-29-1-31-35