Transarterial Chemoembolization of Metastatic Liver Lesions in Patients with Colorectal Cancer
https://doi.org/10.22416/1382-4376-2019-29-5-36-42
Abstract
Aim. To evaluate the efficacy of transarterial chemoembolization in patients with metastases of colorectal cancer in the liver.
Materials and methods. A study aimed at investigating the effect of selective transarterial chemoembolization (TACE) of the hepatic artery on liver metastases in colorectal cancer was conducted at the Oncology Centre of the RZhD Central Clinical Hospital No. 2 named after N.A. Semashko, Moscow. The research basis included data for 10 patients, who had undergone chemoembolization of the hepatic arteries using Biosphere microspheres 50– 100 µm — 25 mg and doxorubicin 50 mg.
Results. Both immediate and long-term results of up to 12 months were evaluated using the RECIST 1.1 scale. A partial response was achieved after 4 TACE treatments in 22.2 % of cases. The stabilization of the oncological process in the liver was observed after 9 TACE treatments in 50 % of cases. Disease progression was noted after 5 procedures in 27.8 % of cases.
Conclusions. Transarterial chemoembolization of metastatic liver lesions in patients with colorectal cancer can be used according to certain indications in specialized centres providing endovascular treatment services.
About the Authors
O. Yu. Stukalova
A.I. Yevdokimov Moscow State University of Medicine and Dentistry;
RZhD Central Clinical Hospital No. 2 named after N.A. Semashko
Russian Federation
Russian Federation
Oksana Yu. Stukalova — Coloproctologist, Coloproctology (Oncology) Department, RZhD Central Clinical Hospital No. 2 named after N.A. Semashko, Post-graduate Student, Department of Oncology and Radiotherapy, A.I. Yevdokimov Moscow State University of Medicine and Dentistry.
127473, Moscow, Delegatskaya str., 20/1.
129128, Moscow, Budayskya str., 2.
G. P. Gens
A.I. Yevdokimov Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
Gelena P. Gens — Dr. Sci. (Med.), Prof., Departmental Head, Department of Oncology and Radiotherapy
127473, Moscow, Delegatskaya str., 20/1.
Z. Kh. Shugushev
RZhD Central Clinical Hospital No. 2 named after N.A. Semashko
Russian Federation
Russian Federation
Zaurbek Kh. Shugushev — Dr. Sci. (Med.), Prof., Principal Cardiologist, Departmental Head, Department of Radiosurgical Methods of Diagnosis and Therapy
129128, Moscow, Budayskya str., 2.
V. V. Maslov
RZhD Central Clinical Hospital No. 2 named after N.A. Semashko
Russian Federation
Russian Federation
Vyacheslav V. Maslov — Cand. Sci. (Med.), Departmental Head, Coloproctology (Oncology) Department
129128, Moscow, Budayskya str., 2.
A. G. Chepurnoy
RZhD Central Clinical Hospital No. 2 named after N.A. Semashko
Russian Federation
Russian Federation
Aleksander G. Chepurnoy — Physician, Radio-endovascular Surgeon, Department of Radiosurgical Methods of Diagnosis and Therapy
129128, Moscow, Budayskya str., 2.
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For citations:
Stukalova O.Yu., Gens G.P., Shugushev Z.Kh., Maslov V.V., Chepurnoy A.G. Transarterial Chemoembolization of Metastatic Liver Lesions in Patients with Colorectal Cancer. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2019;29(5):36-42. (In Russ.) https://doi.org/10.22416/1382-4376-2019-29-5-36-42
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