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Российский журнал гастроэнтерологии, гепатологии, колопроктологии

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Современные представления о роли torque teno virus (TTV) при заболеваниях печени

https://doi.org/10.22416/1382-4376-2020-30-4-7-22

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Аннотация

Цель обзора. Обзор посвящен анализу данных литературы по torque teno virus (вирус TT, TTV), открытому в конце XX столетия.

Основные положения: TTV часто обнаруживают у пациентов с различными вирусными гепатитами, гепатитами без явного вирусного агента, а также у здорового населения. Имеются отдельные данные о биохимических и гистологических изменениях в ткани печени и эпителии желчных протоков при моноинфицировании TTV, подтверждающие возможность прохождения вирусом репликативного цикла в гепатоцитах. Наряду с этим при проведении гибридизации в клетках, пораженных вирусом ТТ, не было отмечено существенных цитопатических (повреждающих клетки) эффектов, характерных для патогенных гепатотропных вирусов. По мере изучения TTV происходила эволюция взглядов на роль вируса для человека. Первые представления о гепатотропности вируса постепенно изменялись по мере получения новых данных о распространенности вируса и его коинфекции с другими вирусами, в том числе вирусами известных гепатитов. Данные о политропизме TTV опровергают возможность его отнесения исключительно к вирусам гепатита. Высокая распространенность вируса ТТ в человеческой популяции указывает на его персистенцию в организме в составе ви-рома и свидетельствует в пользу его непатогенности. Предлагается использовать уровень ДНК TTV в крови пациентов перед трансплантацией органов в качестве эндогенного маркера иммунного статуса организма. Выводы: Высокая распространенность вируса ТТ в человеческой популяции указывает на его персистенцию в организме в составе вирома. Редкое выявление повреждающего действия TTV на клетки печени и эпителиоциты желчных протоков может косвенно свидетельствовать о его условно-патогенных свойствах. 

Об авторах

И. В. Маев
Московский государственный медико-стоматологический университет им. А.И. Евдокимова Министерства здравоохранения Российской Федерации
Россия

Маев Игорь Вениаминович — академик РАН, профессор, доктор медицинских наук, заведующий кафедрой пропедевтики внутренних болезней и гастроэнтерологии.

127473, Москва, ул. Делегатская, д. 20, стр. 1.



Т. И. Карлович
Центральная клиническая больница с поликлиникой Управления делами Президента Российской Федерации
Россия

Карлович Татьяна Игоревна — кандидат медицинских наук, врач поликлиники.

121359, Москва, ул. Маршала Тимошенко, д. 15.



А. И. Бурмистров
Московский государственный медико-стоматологический университет им. А.И. Евдокимова Министерства здравоохранения Российской Федерации
Россия

Бурмистров Александр Игоревич — студент 5-го курса лечебного факультета.

127473, Москва, ул. Делегатская, д. 20, стр. 1.



И. A. Чекмазов
Центральная клиническая больница с поликлиникой Управления делами Президента Российской Федерации
Россия

Чекмазов Игорь Александрович — доктор медицинских наук, первый заместитель главного врача.

121359, Москва, ул. Маршала Тимошенко, д. 15.



Д. Н. Андреев
Московский государственный медико-стоматологический университет им. А.И. Евдокимова Министерства здравоохранения Российской Федерации
Россия

Андреев Дмитрий Николаевич — кандидат медицинских наук, доцент кафедры пропедевтики внутренних болезней и гастроэнтерологии.

127473, Москва, ул. Делегатская, д. 20, стр. 1.



В. И. Решетняк
Московский государственный медико-стоматологический университет им. А.И. Евдокимова Министерства здравоохранения Российской Федерации
Россия

Решетняк Василий Иванович — профессор, доктор медицинских наук, профессор кафедры пропедевтики внутренних болезней и гастроэнтерологии.

127473, Москва, ул. Делегатская, д. 20, стр. 1.



Список литературы

1. Nishizawa T., Okamoto H., Konishi K., Yoshizawa H., Miyakawa Y., Mayumi M. A novel DNA virus (TTV) associated with elevated transaminase levels in posttransfusion hepatitis of unknown etiology. Biochem Biophys Res Commun.1997;241(1):92-7. DOI: 10.1006/bbrc.1997.7765

2. Okamoto H. History of discoveries and pathogenicity of TT viruses. Curr Top Microbiol Immunol. 2009;331:1-20. DOI: 10.1007/978-3-540-70972-5_1

3. Wei Y., Chen M., Yang X., Zhang L., Rao L., Yuan F., et al. Molecular characterization of human Torque Teno virus. Biomed Rep. 2015;3(6):821-6. DOI: 10.3892/br.2015.508

4. Mankotia D.S., Irshad M. Cloning and expression of N22 region of Torque Teno virus (TTV) genome and use of peptide in developing immunoassay for TTV antibodies. Virol J. 2014;11(1):96-103. DOI: 10.1186/1743-422X-11-96

5. Focosi D., Antonelli G., Pistello M., Maggi F. Torquetenovirus: the human virome from bench to bedside. Clin Microbiol Infect. 2016;22(7):589-93. DOI: 10.1016/j.cmi.2016.04.007

6. Biagini P. Classification of TTV and related viruses (anelloviruses). Curr Top Microbiol Immunol. 2009;331:21-33. DOI: 10.1007/978-3-540-70972-5_2

7. Spandole S., Cimponeriu D., Berca L.M., Mihaescu G. Human anelloviruses: an update of molecular, epidemiological and clinical aspects. Arch Virol. 2015;160 (4):893-908. DOI: 10.1007/s00705-015-2363-9

8. Bostan N., Amen N.E., Bokhari H. Current and Future Prospects of Torque Teno Virus. J Vaccines Vaccin. 2013;S1:004. DOI: 10.4172/2157-7560.S1-004

9. Чередниченко Т.В., Филипова Е.А. ТТ-вирусная инфекция. Детские инфекции. 2008;3:43-48.

10. Mushahwar I.K., Erker J.C., Muerhoff A.S., Leary T.P., Simons J.N., Birkenmeyer L.G., et al. Molecular and biophysical characterization of TT virus: evidence for a new virus family infecting humans. Proc Natl Acad Sci USA. 1999;96(6):3177-82. DOI: 10.1073/pnas.96.6.3177

11. Jarkasi N.S., Sekawi Z., Yoke Kqueen C., Othman Z. A Review on the Global Widespread of TTV Infection Among Humans Population. PJSRR. 2018;4(1):10-24.

12. Rezahosseini O., Drabe C.H., S0rensen S.S., Rasmussen A., Perch M., Ostrowski S.R., et al. Torque-Teno virus viral load as a potential endogenous marker of immune function in solid organ transplantation. Transplant Rev (Orlando). 2019;33:137-44. DOI: 10.1016/j.trre.2019.03.004

13. Kakkola L., Bonden H., Hedman L., Kivi N., Moisala S., Julin J., et al. Expression of all six human Torque teno virus (TTV) proteins in bacteria and in insect cells, and analysis of their IgG responses. Virology. 2008;382:182-9. DOI: 10.1099/0022-1317-83-5-979

14. Чернобровкина Т.Я., Литвинова О.С., Янковская Я.Д. TTV-инфекция: клинико-эпидемиологические и диагностические аспекты. Архивъ внутренней медицины. 2016;6(2):28-33. DOI: 10.20514/2226-6704-2016-6-2-28-33.

15. de Oliveira J.C., Nasser T.F., Oda J.M., Aoki M.N., Carneiro J.L., Barbosa D.S., et al. Detection of TTV in peripheral blood cells from patients with altered ALT and AST levels. New Microbiol. 2008;31(2):195-201.

16. Базыкина Е.А., Туркутюков В.Б., Троценко О.Е., Котова В.О., Балахонцева Л.А., Бутакова Л.В. и др. Распространенность и молекулярно-генетическая характеристика вируса гепатита В у ВИЧ-позитивных лиц в Дальневосточном регионе. Инфекция и иммунитет. 2019;9(1):183-92. DOI: 10.15789/2220-7619-2019-1-183-192.

17. Rocchi J., Ricci V., Albani M., Lanini L., Andreoli E., Macera L., et al. Torquetenovirus DNA drives proinflammatory cytokines production and secretion by immune cells via toll-like receptor 9. Virology. 2009;394(2):235-42. DOI: 10.1016/j.virol.2009.08.036

18. Gallian P., Berland Y., Olmer M., Raccah D., de Micco P., Biagini P., et al. TT virus infection in French hemodialysis patients: study of prevalence and risk factors. J Clin Microbiol. 1999;37:2538-42. DOI: 10.1128/JCM.37.8.2538-2542.1999

19. Gallian P., Biagini P., Zhong S., Touinssi M., Yeo W., Cantaloube J.F., et al. TT virus: a study of molecular epidemiology and transmission of genotypes 1,2 and 3. J Clin Virol. 2000;17:43-9.

20. Alzahrani A.J., Dela Cruz D.M., Obeid O.E., Bukhari H.A., Al-Qahtani A.A., Al-Ahdal M.N. Molecular detection of hepatitis B, hepatitis C, and torque teno viruses in drug users in Saudi Arabia. J Med Virol. 2009;81(8):1343-7. DOI: 10.1002/jmv.21487

21. Dencs A., Hettmann A., Szomor K.N., Takacs M. Prevalence and genotyping of group 3 torque teno viruses detected in health care workers in Hungary. Virus Genes. 2009;39(1):39-45. DOI: 10.1007/s11262-009-0369-7

22. El-Taher S.M., Fouad N.A., Fouad M.A., Mahedy A.W., Elnazi A.K. Transfusion-transmitted virus infection in hemodialysis patients in Arar, Saudi Arabia: Prevalence, predictors and genotyping. Saudi J Kidney Dis Transpl. 2015;26:1215-22. DOI: 10.4103/1319-2442

23. Al-Qahtani A.A., Alabsi E.S., AbuOdeh R., Thalib L., El Zowalaty M.E., Nasrallah G.K. Prevalence of anelloviruses (TTV, TTMDV, and TTMV) in healthy blood donors and in patients infected with HBV or HCV in Qatar. Virol J. 2016;13(1):208-13. DOI: 10.1186/s12985-016-0664-6

24. Najafimemar Z., Tabarraei A., Talei G., Moradi A. Prevalence and Genotyping of Torque Teno Virus in HBV/ HIV and Chronic HBV Patients in Iran. Iran Biomed J. 2018(2);22:338-44. DOI: 10.29252/ibj/22.5.338

25. Spandole-Dinu S., Cimponeriu D.G., Craciun A.M., Radu I., Nica S., Toma M., et al. Prevalence of human anelloviruses in Romanian healthy subjects and patients with common pathologies. BMC Infect Dis. 2018;18(1):334-43. DOI: 10.1186/s12879-018-3248-9

26. Cancela F., Ramos N., Mirazo S., Mainardi V., Ge-rona S., Arbiza J. Detection and molecular characterization of Torque Teno Virus (TTV) in Uruguay. Infect Genet Evol. 2016;44:501-6. DOI: 10.1016/j.meegid.2016.08.007

27. Kim H.S., Kim J.S., Park M.J., Song W., Kang H.J., Lee K.M. Distribution of TT virus genotypes and genogroups in 69 healthy and 59 hepatitis B virus infected Korean individuals. Korean J Lab Med. 2007;27(4):257-64. DOI: 10.3343/kjlm.2007.27.4.257

28. Qiu J., Kakkola L., Cheng F., Ye C., Soderlund-Venermo M., Hedman K., et al. Human circovirus TT virus genotype 6 expresses six proteins following transfection of a full-length clone. J Virol. 2005;79(10):6505-10. DOI: 10.1128/JVI.79.10.6505-6510.2005

29. Maggi F., Focosi D., Albani M., Lanini L., Vatteroni M.L., Petrini M., et al. Role of hematopoietic cells in the maintenance of chronic human Torquetenovirus plasma viremia. J Virol. 2010;84(13):6891-3. DOI: 10.1128/JVI.00273-10

30. Kosulin K., Kernbichler S., Pichler H., Lawitschka A., Geyeregger R., Witt V., et al. Post-transplant Replication of Torque Teno Virus in Granulocytes. Front Microbiol. 2018;9:2956. DOI: 10.3389/fmicb.2018.02956

31. Osiowy C., Sauder C. Detection of TT virus in human hair and skin. Hepatol Res. 2000;16(2):155-62. DOI: 10.1016/S1386-6346(99)00046-7

32. Pirouzi A., Bahmani M., Feizabadi M.M., Afkari R. Molecular characterization of Torque teno virus and SEN virus co-infection with HIV in patients from Southern Iran. Rev Soc BrasMed Trop. 2014; 47(3):275-9. DOI: 10.1590/0037-8682-0073-2014

33. Tyschik E.A., Rasskazova A.S., Degtyareva A.V., Rebrikov D.V., Sukhikh G.T. Torque teno virus dynamics during the first year of life. Virol J. 2018;15(1):96-9. DOI: 10.1186/s12985-018-1007-6

34. Wohlfarth P., Leiner M., Schoergenhofer C., Hopfinger G., Goerzer I., Puchhammer-Stoeckl E., et al. Torquetenovirus Dynamics and Immune Marker Properties in Patients Following Allogeneic Hematopoietic Stem Cell Transplantation: A Prospective Longitudinal Study. Biol Blood Marrow Transplant. 2018;24:194-9. DOI: 10.1016/j.bbmt.2017.09.020

35. Comar M., Ansaldi F., Morandi L., Dal Molin G., Foschini P.M., Croce S.L., et al. In situ polymerase chain reaction detection of transfusion-transmitted virus in liver biopsy. J Viral Hepat. 2002;9(2):123-7. DOI: 10.1046/j.1365-2893.2002.00346.x

36. Macera L., Spezia P.G., Medici C., Rofi E., Del Re M., Focosi D., et al. Comparative evaluation of molecular methods for the quantitative measure of torquetenovirus viremia, the new surrogate marker of immune competence. J Med Virol. 2019;1-8. DOI: 10.1002/jmv.25488

37. Kenar Koohi A., Ravanshad M., Rasouli M., Falahi S., Baghban A. Phylogenetic Analysis of Torque Teno Virus in Hepatitis C Virus Infected Patients in Shiraz. Hepat Mon. 2012;12(7):437-41. DOI: 10.5812/hepatmon.6133

38. Ott C., Duret L., Chemin I., Trepo C., Mandrand B., Komurian-Pradel F. Use of a TT virus ORF1 recombinant protein to detect anti-TT virus antibodies in human sera. J Gen Virol. 2000;81:2949-58. DOI: 10.1099/0022-131781-12-2949

39. Tsuda F., Takahashi M., Nishizawa T., Akahane Y., Konishi K., Yoshizawa H., et al. IgM-class antibodies to TT virus (TTV) in patients with acute TTV infection. Hepatol Res. 2001;19(1):1-11. DOI: 10.1016/S1386-6346(00)00086-3

40. Maggi F., Bendinelli M. Immunobiology of the Torque teno viruses and other anelloviruses. Curr Top Microbiol Immunol. 2009;331:65-90. DOI: 10.1007/978-3-540-70972-5_5

41. Mankotia D.S., Irshad M. Development of an Immunoassay for Detection of Torque Teno Virus (TTV) Antibodies Using the N22 Expression Product from TTV Genotype 2. Intervirology. 2017;60(5):207-16. DOI: 10.1159/000487481

42. Tsuda F., Okamoto H., Ukita M., Tanaka T., Akahane Y., Konishi K., et al. Determination of antibodies to TT virus (TTV) and application to blood donors and patients with post-transfusion non-A to G hepatitis in Japan. J Virol Methods. 1999;77:199-206. DOI: 10.1016/s0166-0934(98)00154-2

43. Chen T., Vaisanen E., Mattila P.S., Hedman K., Soderlund-Venermo M. Antigenic diversity and seroprevalences of Torque teno viruses in children and adults by ORF2based immunoassays. J Gen Virol. 2013;94(Pt_2):409-17. DOI: 10.1099/vir.0.046862-0

44. Prescott L.E., Mae Donald D.M., Davidson F. Sequence diversity of TT virus in geographically dispersed human population. J Gen Virol.1999;80:1751-8. DOI: 10.1099/0022-1317-80-7-1751

45. Vasilyev E.V., Trofimov D.Y., Tonevitsky A.G., Ilinsky V.V., Korostin D.O., Rebrikov D.V. Torque Teno Virus (TTV) distribution in healthy Russian population. Virol J. 2009;6(1):134-7. DOI: 10.1186/1743-422X-6-134

46. Tri Rinonce H., Yano Y., Utsumi T., Heriyanto D.S., Anggorowati N., Widasari D.I., et al. Prevalence and genotypic distribution of GB virus C and torque Teno virus among patients undergoing hemodialysis. Mol Med Rep. 2017;15(5):2843-52. DOI: 10.3892/mmr.2017.6281

47. Морозов И.А., Зверкова Е.А., Кюрегян К.К., Карлсен А.А., Исаева О.В., Ильченко Л.Ю. и др. Вирусы рода Anelloviridae при хронической патологии печени. Экспериментальная и клиническая гастроэнтерология. 2015;7(119):4-11.

48. Осипкина О.В., Воропаев Е.В., Мицура В.М., Зятьков А.А., Терешков Д.В., Переволоцкая Т.В. и др. Torquetenovirus: распространенность и особенности ПЦР-диагностики. Проблемы здоровья и экологии. 2018;3(57):85-90.

49. Abraham P., John G.T., Raghuraman S., Radhakrishnan S., Thomas P.P., Jacob C.K., et al. GB virus C/ hepatitis G virus and TT virus infections among high risk renal transplant recipients in India. J Clin Virol. 2003;28(1):59-69. DOI: 10.1016/s1386-6532(02)00239-1

50. Tyschik E.A., Shcherbakova S.M., Ibragimov R.R., Rebrikov D.V. Transplacental transmission of torque Teno virus. Virol J. 2017;14(1):92. DOI: 10.1186/s12985-017-0762-0

51. Naganuma M., Tominaga N., Miyamura T., Soda A., Moriuchi M., Moriuchi H. TT virus prevalence, viral loads and genotypic variability in saliva from healthy Japanese children. Acta Paediatr. 2008;97(12):1686-90. DOI: 10.1111/j.1651-2227.2008.00962.x

52. McElvaniaTeKippe E., Wylie K.M., Deych E., Sodergren E., Weinstock G., Storch G.A. Increased prevalence of anellovirus in pediatric patients with fever. PLoS One. 2012;7(11):e50937. DOI: 10.1371/journal.pone.0050937

53. Vecchia A.D., Kluge M., dos Santos da Silva J.V., Comerlato J., Rodrigues M.T., Fleck J.D., et al. Presence of Torque teno virus (TTV) in tap water in public schools from Southern Brazil. Food Environ Virol. 2013;5(1):41-5. DOI: 10.1007/s12560-012-9096-7

54. Charest A.J., Plummer J.D., Long S.C., Carducci A., Verani M., Sidhu J.P. Global occurrence of Torque teno virus in water systems. J Water Health. 2015;13(3):777-89. DOI: 10.2166/wh.2015.254

55. Chikasue K., Kimura M., Ikeda K., Ohnishi T., Kawanishi S., Iio T., et al. Detection of Torque teno virus DNA in exhaled breath by polymerase chain reaction. Acta Med Okayama.2012;66:387-97. DOI: 10.18926/AMO/48963

56. Haloschan M., Bettesch R., Gorzer I., Weseslindtner L., Kundi M., Puchhammer-Stockl E. TTV DNA plasma load and its association with age, gender, and HCMV IgG serostatus in healthy adults. Age (Dordr). 2014;36(5):9716. DOI: 10.1007/s11357-014-9716-2

57. Михайлов М.И., Кюрегян К.К., Исаева О.В., Поляков А.Н., Попова О.Е. TTV — новый вирус, ассоциированный с посттрансфузионным гепатитом. Рос журн гастроэнтерол гепатол колопроктол. 1999;9(3):36-40.

58. Ukita M., Okamoto H., Kato N., Miyakawa Y., Mayumi M. Excretion into bile of a novel unenveloped DNA virus (TT virus) associated with acute and chronic non-A-G hepatitis. J Infect Dis. 1999;179(5):1245-8. DOI: 10.1086/314716

59. Шарафанова Т.И., Ильченко Л.Ю., Серова Т.И., Шепелева С.Д., Ткачев В.Д. Решетняк В.И. Морфологические изменения в ткани печени у больных, инфицированных вирусом гепатита ТТ. Российский гастроэнтерологический журнал. 2001;2:158-62.

60. Ross R.S., Viazov S., Runde V., Schaefer U.W., Roggendorf M. Detection of TT virus DNA in specimens other than blood. J Clin Virol. 1999;13(3):181-4. DOI: 10.1016/s1386-6532(99)00015-3

61. Luo K.X., Liang W., He H., Yang S., Wang Y., Xiao H., et al. Experimental infection of nonenveloped DNA virus (TTV) in Rhesus monkey. J Med Virol. 2000;61(1):159-64. DOI: 10.1002/(sici)1096-9071(200005)61:1<159::aid-jmv26>3.0.co;2-h

62. Tawara A., Akahane Y., Takahishi M., Nishizawa T., Ishikawa T., Okamoto H. Transmission of human TT virus of genotype 1a to chimpanzees with fecal supernatant or serum from patients with acute TT infection. Biochem-Biophys Res Commun. 2000;278(2):470-6. DOI: 10.1006/bbrc.2000.3825

63. Matsumoto A., Yeo A.E., Shih J.W., Tanaka E., Kiyosawa K., Alter H.J. Transfusion-associated TT virus infection and its relationship to liver disease. Hepatology. 1999;30(1):283-8. DOI: 10.1002/hep.510300118

64. Решетняк В.И., Логинов А.С., Ильченко Л.Ю., Шарафанова Т.И., Ильченко Л.Ю., Шепелева С.Д., и Др. HGV- и TTV-инфекции у больных хроническими заболеваниями печени. Терапевтический архив. 2000;72:9-13.

65. Moriyama M., Matsumura H., Shimizu T., Shioda A., Kaneko M., Miyazawa K., et al. Histopathologic impact of TT virus infection on the liver of type C chronic hepatitis and liver cirrhosis in Japan. J Med Virol. 2001;64(1):74-81. DOI: 10.1002/jmv.1020

66. Okamoto H., Ukita M., Nishizawa T., Kishimoto J., Hoshi Y., Mizuo H., et al.Circular double-stranded forms of TT virus DNA in the liver. J Virol. 2000;74(11):5161-70. DOI: 10.1128/jvi.74.11.5161-5167.2000

67. Magu S.K., Kalghatgi A.T., Bhagat M.R. Incidence and clinical implication of TT virus in patients with hepatitis and its frequency in blood donors in India. Med J Armed Forces India. 2015;71(4):340-4. DOI: 10.1016/j.mjafi.2015.06.023

68. Mazzola J.C., Saito P.K., Yamakawa R.H., Watanabe M.A., da Silva Junior W.V., Matta A.C., et al. Prevalence of Torque teno virus in healthy donors of Par-and State, southern Brazil. Rev Bras Hematol Hemoter. 2015;37(5):336-40. DOI: 10.1016/j.bjhh.2015.07.005

69. Wolff C., Diekmann A., Boomgaarden M., Korner M.M., Kleesiek K. Viremia and excretion of TT virus in immunosuppressed heart transplant recipients and in immunocompetent individuals. Transplantation. 2000;69:351-6. DOI: 10.1097/00007890-200002150-00007

70. Takayama S., Miura T., Matsuo S., Taki M., Su-gii S. Prevalence and persistence of a novel DNA TT virus (TTV) infection in Japanese haemophiliacs. Br J Haematol. 1999;104(3):626-9. DOI: 10.1046/j.1365-2141.1999.01207.x

71. Yokozaki S., Toyoda H., Nakano I., Katano Y., Ebata M., Fukuda Y., et al. Infection with TT virus, a novel transfusion-transmissible DNA virus, in haemophiliacs and in blood products. Br J Haematol. 1999;105(4):1114-9. DOI: 10.1046/j.1365-2141.1999.01452.x

72. Grabarczyk P., Brojer E., Windyga J., Lopaciuk S., Klukowska A., Mikulska M. GBV-C/HGV and TTV infection markers in Polish blood donors and haemophilia patients. Przegl Epidemiol. 2006;60:581-8.

73. Ali S., van Pelt J.F., Verslype C., Nevens F., Fevery J., Yap S.H. TT virus infection in acute and chronic liver diseases and in patients regularly receiving blood products in Belgium. Acta Gastroenterol Belg. 2004;67(2):161-5.

74. de Castro Amarante M.F., Kashima S., Covas D.T. TT virus (TTV) genotyping in blood donors and multiple transfused patients in Brazil. Virus Genes. 2007;35(3):503-9. DOI: 10.1007/s11262-007-0124-x

75. Hu Y.W., Al-Moslih M.I., Al Ali M.T., Uzicanin S., Perkins H., Yi Q.L., et al. Clinical outcome of frequent exposure to Torque Teno virus (TTV) through blood transfusion in thalassemia patients with or without hepatitis C virus (HCV) infection. J Med Virol. 2008;80(2):365-71. DOI: 10.1002/jmv.21070

76. Jalali H., Mahdavi M.R., Zaeromali N. Torque Teno Virus (TTV) Among в-Thalassemia and Haemodialysis Patients in Mazandaran Province (North of Iran). Int J Mol Cell Med. 2017;6:56-60.

77. Rivanera D., Lozzi M.A., Idili C., Lilli D. Prevalence of TT virus infection in Italian dialysis patients. Pathol Biol (Paris). 2009;57(1):97-100. DOI: 10.1016/j.pat-bio.2008.07.014

78. Irshad M., Mandal K., Singh S., Agarwal S.K. Torque teno virus infection in hemodialysis patients in North India. Int Urol Nephrol. 2010;42(4):1077-83. DOI: 10.1007/s11255-009-9648-4

79. Ataei B., Emami Naeini A., Khorvash F., Yazdani M.R., Javadi A.A. Prevalence of transfusion transmitted virus infection in hemodialysis patients and injection drug users compared to healthy blood donors in Isfahan, Iran. Gastroenterol Res Pract. 2012;2012:671927. DOI: 10.1155/2012/671927

80. Massau A., Martins C., Nachtigal G.C., Araujo A.B., Rossetti M.L., Niel C., et al. The high prevalence of Torque teno virus DNA in blood donors and haemodialysis patients in southern Brazil. Mem Inst Oswaldo Cruz.2012;107:684-6. DOI: 10.1590/s0074-02762012000500017

81. Takemoto A.Y., Okubo P., Saito P.K., Yamakawa R.H., Watanabe M.A., Verissimo da Silva Junior W., et al. Torque teno virus among dialysis and renal-transplant patients. Braz J Microbiol. 2015;46(1):307-11. DOI: 10.1590/S1517-838246120131195

82. Burra P., Masier A., Boldrin C., Calistri A., Andreoli E., Senzolo M., et al. Torque Teno Virus: any pathological role in liver transplanted patients? Transpl Int.2008;21(10):972-9. DOI: 10.1111/j.1432-2277.2008.00714.x

83. Young J.C., Chehoud C., Bittinger K., Bailey A., Diamond J.M., Cantu E., et al. Viral metagenomics reveal blooms of anelloviruses in the respiratory tract of lung transplant recipients. Am J Transplant. 2015;15(1):200-9. DOI: 10.1111/ajt.13031

84. Gorzer I., Haloschan M., Jaksch P., Klepetko W., Puchhammer-Stockl E. Plasma DNA levels of Torque teno virus and immunosuppression after lung transplantation. J Heart Lung Transplant. 2014;33(3):320-3. DOI: 10.1016/j.healun.2013.12.007

85. Gorzer I., Jaksch P., Strassl R., Klepetko W., Puchhammer-Stockl E. Association between plasma Torque teno virus level and chronic lung allograft dysfunction after lung transplantation. J Heart Lung Transplant. 2017;36(3):366-8. DOI: 10.1016/j.healun.2016.10.011

86. Beland K., Dore-Nguyen M., Gagne M.J., Patey N., Brassard J., Alvarez F., et al. Torque Teno virus in children who underwent orthotopic liver transplantation: new insights about a common pathogen. J Infect Dis. 2014;209(2):247-54. DOI: 10.1093/infdis/jit423

87. Akbari H., Piroozmand A., Dadgostar E., Nikoueine-jad H., Chitsazian Z., Einollahi B., et al. Prevalence of Transfusion-transmitted Virus (TTV) Infection and its Association with Renal Post-transplantation Complications in Iran. Int J Organ Transplant Med. 2018;9:126-31.

88. Simmonds P., Davidson F., Lycett C., Prescott L.E., MacDonald D.M., Ellender J., et al. Detection of a novel DNA virus (TTV) in blood donors and blood products. Lancet. 1998;18;352(9123):191-5. PMID: 9683208 DOI: 10.1016/s0140-6736(98)03056-6

89. Pisani G., Cristiano K., Wirz M., Bisso G., Beneduce F., Morace G., et al. Prevalence of TT virus in plasma pools and blood products. Br J Haematol. 1999;106(2):431-5. DOI: 10.1046/j.1365-2141.1999.01568.x

90. AbuOdeh R., Al-Mawlawi N., Al-Qahtani A.A., Bohol M.F., Al-Ahdal M.N., Hasan H.A., et al. Detection and genotyping of torque teno virus (TTV) in healthy blood donors and patients infected with HBV or HCV in Qatar. J Med Virol. 2015;87(7):1184-91. DOI: 10.1002/jmv.24146

91. Charlton M., Adjei P., Poterucha J. TT virus infection in north American blood donors, patients with fulminant hepatic failure and cryptogenic cirrhosis. Hepatology. 1998;28(3):839-42. DOI: 10.1002/hep.510280335

92. Konishi K., Ueyama T. Involvement of TTV, a new infections factor in post-transfusion hepatitis, non A — non G. Nihon Rinsho. 1999;57:1279-84.

93. Kanda Y., Tanaka Y., Kami M., Saito T., Asai T., Izutsu K., et al. TT virus in bone marrow transplant recipients. Blood. 1999;93:2485-90. DOI: 10.1182/blood.v93.8.2485.408k06_2485_2490

94. Simonetta F., Pradier A., Masouridi-Levrat S., van Delden C., Giostra E., Morard I., et al. Torque Tenovirus load and acute rejection after orthotopic liver transplantation. Transplantation. 2017;101(7):e219-21. DOI: 10.1097/TP.0000000000001723

95. Mikhailov M.I., Kyuregyan К.К., Potytyannik О.N. Transfusion Transmitted Virus — the possibility of sexual transmission. Antivir Ther. 10th International Symposium on Viral Hepatitis and Liver Disease. 9-13 April 2000, Atlanta, Georgia, USA. Abstracts. 2000; 5 (Suppl 1):1-82.

96. Huang Y.H., Wu J.C., Lin C.C., Sheng W.Y., Lee P.C., Wang Y.J., et al. D. Prevalence and risk factor analysis of TTV infection in prostitutes. J Med Virol. 2000;60(4):393-5. DOI: 10.1002/(sici)1096-9071(200004)60:4<393::aid-jmv5>3.0.co;2-6

97. Yazici M., Comert M.R., Mas R., Guney C., Cinar E., Kocar I.H. Transfusion-transmitted virus prevalence in subjects at high risk of sexually transmitted infection in Turkey. Clin Microbiol Infect. 2002;8(6):363-7. DOI: 10.1046/j.1469-0691.2002.00423.x

98. Inami T., Konomi N., Arakawa Y., Abe K. High prevalence of TT virus DNA in human saliva and semen. J Clin Microbiol. 2000;38(6):2407-8.

99. Matsubara H., Michitaka K., Horiike N., Kihana T., Yano M., Mori T., et al. Existence of TT virus DNA and TTV-like mini virus DNA in infant cord blood: mother-to-neonatal transmission. Hepatol Res. 2001;21(3):280-7. DOI: 10.1016/s1386-6346(01)00115-2

100. Xin X., Xiaoguang Z., Ninghu Z., Youtong L., Liu-mei X., Boping Z. Mother-to-infant vertical transmission of transfusion transmitted virus in South China. J Perinat Med. 2004;32(5):404-6. DOI: 10.1515/JPM.2004.136

101. Schroter M., Polywka S., Zollner B., Schafer P., Laufs R., Feucht H.H. Detection of TT virus DNA and GB virus type C/Hepatitis G virus RNA in serum and breast milk: determination of mother-to-child transmission. J Clin Microbiol. 2000;38(2):745-7.

102. Gerner P., Oettinger R., Gerner W., Falbrede J., Wirth S. Mother-to-infant transmission of TT virus: prevalence, extent and mechanism of vertical transmission. Pediatr Infect Dis J. 2000;19:1074-7. DOI: 10.1097/00006454-200011000-00009

103. Lin C., Kyono W., Tongson J., Chua P.K., Easa D., Yanagihara R., et al. Fecal excretion of a novel human circovirus, TT virus, in healthy children. Chin Diagn Lab Immunol. 2000;7(6):960-3. DOI: 10.1128/cdli.7.6.960-963.2000

104. Учайкин В.Ф., Чередниченко Т.В., Самохвалов Е.И., Филипова Е.В., Чаплыгина Г.В., Ковалев О.Б., Конев В.А. Современные представления о ТТ-вирусной инфекции у детей. Детские инфекции. 2010;9(4):15-8.

105. Inaba N., Oshima K., Okajima Y., Nagase T. TTV materno-infantile infection — a study of the TTV frequency. Nippon Rinsho. 1999;57:1406-9.

106. Goto K., Sugiyjama K., Ando T., Mizutani F., Terabe K., Tanaka K., et al. Detection rates of TT virus DNA in serum of umbilical cord blood, breast milk and saliva. Tohoku J Exp Med. 2000;191(4):203-7. DOI: 10.1620/tjem.191.203

107. Manzin A., Mallus F., Macera L., Maggi F., Blois S. Global impact of Torque teno virus infection in wild and domesticated animals. J Infect Dev Ctries. 2015;9:562-70. DOI: 10.3855/jidc.6912

108. Naoumov N.V., Petrova E.P., Thomas M.G., Williams R. Presence of a newly described human DNA virus (TTV) in patients with liver disease. Lancet. 1998;352(9123):195-7. DOI: 10.1016/S0140-6736(98)04069-0

109. Kanda T., Yokosuka O., Ikeuchi T., Seta T., Kawai S., Imazeki F., et al. The role of TT virus infection in acute viral hepatitis. Hepatology. 1999;29(6):1905-8. DOI: 10.1002/hep.510290613

110. Fabris P., Biasin M.R., Infantolino D., Tositti G., Ven-za E., Floreani A., et al. TTV infection in patients with acute hepatitis of defined aetiology and in acute non-A-E hepatitis. J Hepatol. 2000;32(4):661-5. DOI: 10.1016/s0168-8278(00)80229-9

111. Kikuchi K., Miyakawa H., Abe K., Kako M., Katayama K., Fukushi S., et al. Indirect evidence of TTV replication in bone marrow cells, but not in hepatocytes, of a subacute hepatitis/aplastic anemia patient. J Med Virol. 2000;61(1):165-70. DOI: 10.1002/(sici)1096-9071(200005)61:1<165::aid-jmv27>3.0.co;2-f

112. Rodrfguez-Inigo E., Casqueiro M., Bartolome J., Ortiz-Movilla N., Lopez-Alcorocho J.M., Herrero M., et al. Detection of TT virus DNA in liver biopsies by in situ hybridization. Am J Pathol. 2000;156(4):1227-34. DOI: 10.1016/S0002-9440(10)64993-0

113. Tanaka Y., Mizokami M., Orito E., Ohno T., Nakano T., Kato T., et al. Lack of integrated TT virus (TTV) genomes into cellular DNA in infected human hematopoietic cells. Leuk Lymphoma. 2000;38(3-4):411-7. DOI: 10.3109/10428190009087033

114. Mariscal L.F., Lopez-Alcorocho J.M., Rodriguez-Inigo E., Ortiz-Movilla N., de Lucas S., Bartolome J., et al. TT virus replicates in stimulated but not in nonstimulated peripheral blood mononuclear cells. Virology. 2002; 301(1):121-9. DOI: 10.1006/viro.2002.1545

115. Focosi D., Macera L., Boggi U., Nelli L.C., Maggi F. Short-term kinetics of torque teno virus viraemia after induction immunosuppression confirm T lymphocytes as the main replication-competent cells. J Gen Virol. 2015;96(Pt_1):115-7. DOI: 10.1099/vir.0.070094-0

116. Ohbayashi H., Tanaka Y., Ohoka S., Chinzei R., Kakinuma S., Goto M., et al. TT virus is shown in the liver by in situ hybridization with a PCR-generated probe from the serum TTV-DNA. J Gastroenterol Hepatol. 2001;16(4):424-8. DOI: 10.1046/j.1440-1746.2001.02460.x

117. Kazemi M.J., Yaghobi R., Iravani Saadi M., Geramizadeh B., Moayedi J. Association Between TT Virus Infection and Cirrhosis in Liver Transplant Patients. Hepat Mon. 2015;15:e28370. DOI: 10.5812/hepatmon.28370

118. Albert E., Solano C., Pascual T., Torres I., Macera L., Focosi D., et al. Dynamics of Torque Teno virus plasma DNAemia in allogeneicstem cell transplant recipients. J Clin Virol. 2017;94:22-8. DOI: 10.1016/j.jcv.2017.07.001

119. Deng X., Terunuma H., Handema R., Sakamoto M., Kitamura T., Ito M., et al. Higher prevalence and viral blood of TT virus in saliva that in the corresponding serum: another possible transmission route and replication site of TT virus. J Med Virol. 2000;62(4):531-7. DOI: 10.1002/1096-9071(200012)62:4<531::AID-JMV20>3.0.CO;2-C

120. Kincaid R.P., Sullivan C.S. Virus-Encoded micro-RNAs: An Overview and a Look to the Future. PLo-SPathog. 2012;8(12):e1003018. DOI: 10.1371/journal.ppat.1003018

121. Boss I.W., Renne R. Viral miRNAs: tools for immune evasion. CurrOpin Microbiol. 2010;13(4):540-5. DOI: 10.1016/j.mib.2010.05.017

122. Cullen B.R. MicroRNAs as mediators of viral evasion of the immune system. Nat Immunol.2013; 14(3):205-10. DOI: 10.1038/ni.2537

123. Kincaid R.P., Burke J.M., Cox J.C., de Villiers E.M., Sullivan C.S. A Human Torque Teno Virus Encodes a MicroRNA That Inhibits Interferon Signaling. PLo-SPathog. 2013;9(12):e1003818. DOI: 10.1371/journal.ppat.1003818

124. Vignolini T., Macera L., Antonelli G., Pistello M., Maggi F., Giannecchini S. Investigation on torqueteno-virus (TTV) microRNA transcriptome in vivo. Virus Res. 2016;217:18-22. DOI: 10.1016/j.virusres.2016.03.003

125. Garbuglia A.R., Grasso F., Don M.G., Mochi S., Conti P., De Lutiis M.A., et al. TT virus infection: role of interferons, interleukin-28 and 29, cytokines and antiviral proteins. Int J Immunopathol Pharmacol. 2007;20(2):249-58. DOI: 10.1177/039463200702000205

126. Zanotta N., Maximova N., Campisciano G., Del Savio R., Pizzol A., Casalicchio G., et al. Up-regulation of the monocyte chemotactic protein-3 in sera from bone marrow transplanted children with torquetenovirus infection. J Clin Virol. 2015;63:6-11. DOI: 10.1016/j.jcv.2014.11.028

127. Garcia-Alvarez M., Berenguer J., Alvarez E., Guzman-Fulgencio M., Cosin J., Miralles P., et al. Association of torque teno virus (TTV) and torque teno mini virus (TTMV) with liver disease among patients coinfected with human immunodeficiency virus and hepatitis C virus. Eur J Clin Microbiol Infect Dis. 2013;32(3):289-97. DOI: 10.1007/s10096-012-1744-1

128. Maggi F., Focosi D., Statzu M., Bianco G., Costa C., Macera L., et al. Early Post-Transplant Torquetenovirus Viremia Predicts Cytomegalovirus Reactivations In Solid Organ Transplant Recipients. Sci Rep. 2018;8(1):15490. DOI: 10.1038/s41598-018-33909-7

129. Handala L., Descamps V., Morel V., Castelain S., Frangois C., Duverlie G., et al. No correlation between Torque Teno virus viral load and BK virus replication after kidney transplantation. J Clin Virol. 2019;116:4-6. DOI: 10.1016/j.jcv.2019.03.018

130. Осипова Л.А., Макарова Т.Е., Медведева Е.А. Опыт лечения хронического вирусного гепатита, вызванного ТТ-вирусом. Здравоохранение Дальнего Востока. 2018;1:41-3.

131. Hayashi K., Fukuda Y., Hayakawa T., Kumada T., Nakano S. TT virus (TTV) infection in patients with acute hepatitis. Nihon Rinsho. 1999;57:1322-5.

132. Tangkijvanich P., Theamboonlers A., Hirsch P., Kullavanijaya P., Suwangool P., Poovorawan Y. TT virus infection in chronic liver disease. Hepatogastroenterol. 1999;46:1053-8.

133. Kato T., Mizokami M., Orito E., Nakano T., Tanaka Y., Ueda R., et al. High prevalance of TT virus infection in Japanese patients with liver diseases and in blood donors. J Hepatol. 1999;31(2):221-7. DOI: 10.1016/s0168-8278(99)80217-7

134. Gerner P. TT virus infection in healthy children and in children with chronic hepatitis B or C. J Pediatr. 2000;136(5):606-10. DOI: 10.1067/mpd.2000.105230

135. Das K., Kar P., Gupta R.K., Das B.C. Role of transfusion-transmitted virus in acute viral hepatitis and fulminant hepatic failure of unknown etiology. J Gastroenterol Hepatol. 2004;19(4):406-12. DOI: 10.1111/j.1440-1746.2003.03308.x

136. Asim M., Singla R., Gupta R.K., Kar P. Clinical & molecular characterization of human TT virus in different liver diseases. Indian J Med Res. 2010;131:545-54.

137. Громова Н.И., Гранкова Т.М., Гордейчук И.В., Кюрегян К.К., Ильченко Л.Ю., Михайлов М.И. Влияние инфицирования вирусом ТТ на течение и эффективность лечения хронических вирусных гепатитов. Инфекционные болезни. 2011;9:14-8.

138. Shibayama T., Igari T., Tsuda F. The prevalence of TTV infection in non-A to G chronic liver disease, especially nonA to G hepatocellular carcinoma, and the clinical significance of TTV infection. Nihon Rinsho. 1999;57:1356-61.

139. Cao K., Mizokami M., Orito E., Ding X., Ge X.M., Huang G.Y., et al. TT virus infection among IVDUs in South Western China. Scand J Infect Dis. 1999;31(1):21-5. DOI: 10.1080/00365549950161835

140. Gimenez-Barcons M., Forns X., Ampurdanes S., Guilera M., Soler M., Soguero C., et al. Infection with a novel human DNA virus (TTV) has no pathogenic significance in patients with liver diseases. J Hepatol. 1999;30(6):1028-34. DOI: 10.1016/s0168-8278(99)80256-6

141. Rosa A.S., Araujo O.C., Savassi-Ribas F., Fernandes C.A., Coelho H.S., Niel C., et al. Prevalence of occult hepatitis B virus infection and Torque teno virus infection and their association with hepatocellular carcinoma in chronic hepatitis C patients. Virus Res. 2017; 242:16672. DOI: 10.1016/j.virusres.2017.09.022

142. Hagiwara H., Hayashi N., Mita E., Oshita M., Kobayashi I., Iio S., et al. Influence of transfusion-transmitted virus infection on the clinical features and response to interferon therapy in Japanese patients with chronic hepatitis C. J Viral Hepat. 1999;6:463-9.

143. Nishizawa Y., Tanaka E., Orii K., Rokuhara A., Ichijo T., Yoshizawa K., et al. Clinical impact of genotype 1 TT virus infection in patients with chronic hepatitis C and response of TT virus to alpha-interferon. J Gastroenterol Hepatol. 2000;15(11):1292-7. DOI: 10.1046/j.1440-1746.2000.2342.x

144. Cleavinger P.J., Persing D.H., Li H., Moore S.B., Charlton M.R., Sievers C., et al. Prevalence of TT virus infection in blood donors with elevated ALT in the absence of known hepatitis markers. Am J Gastroenterol. 2000; 95(3):772-6. DOI: 10.1111/j.1572-0241.2000.01820.x

145. Piaggio F., Dodi F., Bottino G., Andorno E., Gentile R., Ferrari C., et al. Torque TenoVirus — cause of viral liver disease following liver transplantation: a case report. Transplant Proc. 2009;41(4):1378-9. DOI: 10.1016/j.transproceed.2009.03.047

146. Abe K., Okano T., Miyasaka A., Sato S., Suzuki K., Sato S., et al. Clinical characteristics of acute non-A to G hepatitis caring TTV DNA. Nihon Rinsho. 1999;57:1285-9.

147. Sakamoto M., Akahane Y. TTV superinfection on acute hepatitis B. Nihon Rinsho. 1999;57:1326-9.

148. Ikeda H., Takasu M., Inoue K., Okamoto H., Miyakawa Y., Mayumi M.Infection with an unenveloped DNA virus (TTV) in patients with acute or chronic liver disease of unknown etiology and in those positive for hepatitis C virus RNA. J Hepatol. 1999; 30(2):205-12. DOI: 10.1016/s0168-8278(99)80063-4

149. Watanabe H., Saito T., Kawamata O., Shao L., Aoki M., Terui Y., et al. Clinical implications of TT virus superinfection in patients with chronic hepatitis C. Am J Gastroenterol. 2000;95(7):1776-80. DOI: 10.1111/j.1572-0241.2000.02177.x

150. Kao J.H., Chen W., Chen P.J., Lai M.Y., Chen D.S. TT virus infection in patients with chronic hepatitis B or C: influence on clinical, histological and virologicalfeatures. J Med Virol. 2000;60(4):387-92. DOI: 10.1002/(sici)1096-9071(200004)60:4<387::aid-jmv4>3.0.co;2-z

151. Kristian P., Schreter I., Siegfried L., Jarcuska P., Jarcuska P., Paralicova Z., et al. Impact of TTV and SENV infection in chronic hepatitis B or C on liver histology and therapy outcome. Bratisl Lek Listy. 2010;111:629-34.

152. Alavi S., Sharifi Z., Valeshabad A.K., Nourbakhsh K., Shamsian B.S., Arzanian M.T., et al. Clinical outcomes of Torque teno virus-infected thalassemic patients with and without hepatitis C virus infection. Korean J Hematol. 2011;46(2):123-7. DOI: 10.5045/kjh.2011.46.2.123

153. Hasebe C., Kawashima T., Kohgo Y. Histological findings of TTV-positive non-B, non-C chronic hepatitis patients. Nihon Rinsho. 1999;57:1350-5.

154. Hu Z.J., Lang Z.W., Zhou Y.S., Yan H.P., Huang D.Z., Chen W.R., et al. Clinicopathological study on TTV infection in hepatitis of unknown etiology. World J Gastroenterol. 2002;8:288-93. DOI: 10.3748/wjg.v8.i2.288

155. Хомерики С.Г., Ильченко Л.Ю., Морозов И.А., Карлович Т.И. Клинико-морфологические особенности поражения печени у больных, инфицированных вирусом гепатита ТТ. Мир вирусных гепатитов. 2006;2:2-8.

156. Колтунов А.С., Алексеенко С.А., Евсеев А.Н.,Колтунов С.С. Клинико-морфологическая характеристика хронического гепатита, ассоциированного с TTV-инфекцией. Дальневосточный медицинский журнал. 2013;3:12-4.

157. Морозов И.А., Ильченко Л.Ю., Кюрегян К.К., Карлсен А.А., Федюкина Е.С., Федоров И.Г. и др. Первые два случая хронического гепатита, ассоциированного с Torque teno midi virus (TTMDV), genus Gammatorquevirus. Архивъ внутренней медицины. 2017;1(33):71-7. DOI: 10.20514/2226-6704-2017-7-1-71-77.

158. Tokita H., Murai S., Kamitsukasa H. Influence of TT virus on the histopathological features of nonalcoholic fatty liver disease. Hepatology Research. 2001;19(3):197-211. DOI: 10.1016/s1386-6346(00)00124-8

159. Arakawa Y., Shioda A., Moriyama M. Incidence of TT virus infection in patients with non-A to G liver disease. Nihon Rinsho. 1999;57:1290-4.

160. Wang J.T., Lee C.Z., Kao J.H., Sheu J.C., Wang T.H., Chen D.S. Incidence and clinical presentation of posttransfusion TT virus infection in prospectively followed transfusion recipients: emphasis on its relevance to hepatitis. Transfusion.2000;40(5):596-601. DOI: 10.1046/j.1537-2995.2000.40050596.x

161. De Vlaminck I., Khush K.K., Strehl C., Kohli B., Luikart H., Neff N.F., et al. Temporal response of the human virome to immunosuppression and antiviral therapy. Cell. 2013;155(5):1178-87. DOI: 10.1016/j.cell.2013.10.034

162. Solis M., Velay A., Gantner P., Bausson J., Filipputtu A., Freitag R., et al. Torquetenovirus viremia for early prediction of graft rejection after kidney transplantation. J Infect. 2019;79:56-60. DOI: 10.1016/j.jinf.2019.05.010

163. Giacconi R., Maggi F., Macera L., Pistello M., Provinciali M., Giannecchini S., et al. Torquetenovirus (TTV) load is associated with mortality in Italian elderly subjects. Exp Gerontol. 2018;112(2):103-11. DOI: 10.1016/j.exger.2018.09.003

164. Kaczorowska J., van der Hoek L. Human Anelloviruses: diverse, omnipresent and commensal members of the vi-rome. FEMS Microbiol Rev. 2020;44(3):305-13. DOI: 10.1093/femsre/fuaa007

165. Focosi D., Macera L., Pistello M., Maggi F. Torque Teno virus viremia correlates with intensity of maintenance immunosuppression in adult orthotopic liver transplant. J Infect Dis. 2014;210(4):667-8. DOI: 10.1093/infdis/jiu209

166. Schiemann M., Puchhammer-Stockl E., Eskandary F., Kohlbeck P., Rasoul-Rockenschaub S., Heilos A., et al. Torque Teno Virus Load — Inverse Association with Antibody-Mediated Rejection after Kidney Transplantation. Transplantation. 2017;101(2):360-7. DOI: 10.1097/TP.0000000000001455

167. Ruiz P., Martinez-Picola M., Santana M., Munoz J., Perez-Del-Pulgar S., Koutsoudakis G., et al. Torque Teno Virus is associated with the state of immune suppression early after liver transplantation. Liver Transpl. 2019;25(2):302-10. DOI: 10.1002/lt.25374

168. Kulifaj D., Durgueil-Lariviere B., Meynier F., Munteanu E., Pichon N., Dube M., et al. Development of a standardized real time PCR for Torque teno viruses (TTV) viral load detection and quantification: A new tool for immune monitoring. J Clin Virol. 2018;105:118-27. DOI: 10.1016/j.jcv.2018.06.010

169. Lefrere J.S., Rendot-Thoraval F., Lefrere F., Kanfer A., Mariotti M., Lerable J., et al. Natural history of the TT virus infection through flow up of TTV DNA positive multiple-transfused patients. Blood. 2000;95(1):347-51. DOI: 10.1182/blood.v95.1.347.001k42_347_351

170. Strassl R., Schiemann M., Doberer K., Gorzer I.Puchhammer-Stockl E., Eskandary F., Kikic Z., et al. Quantification of Torque Teno Virus Viremia as a Prospective Biomarker for Infectious Disease in Kidney Allograft Recipients. J Infect Dis. 2018;218(8):1191-9. DOI: 10.1093/infdis/jiy306

171. Schmitz J., Kobbe G., Kondakci M., Schuler E., Magorsch M., Adams O. The Value of Torque Teno Virus (TTV) as a Marker for the Degree of Immunosuppression in Adult Patients after Hematopoietic Stem Cell Transplantation (HSCT). Biol Blood Marrow Transplant. 2020;26(4):643-50. DOI: 10.1016/j.bbmt.2019.11.002

172. Frye B.C., Bierbaum S., Falcone V., Kohler T.C., Gasplmayr M., Hettich I., et al. Kinetics of Torque Teno Virus-DNA Plasma Load Predict Rejection in Lung Transplant Recipients. Transplantation. 2019;103(4):815-22. DOI: 10.1097/TP.0000000000002436

173. Doberer K., Schiemann M., Strassl R., Haupenthal F., Dermuth F., Gorzer I., et al. Torque teno virus for risk stratification of graft rejection and infection in kidney transplant recipients-A prospective observational trial. Am J Transplant. 2020. DOI: 10.1111/ajt.15810

174. Fernandez-Ruiz M. Torque Teno virus load as a surrogate marker for the net state of immunosuppression: the beneficial side of the virome. Am J Transplant. 2020. DOI: 10.1111/ajt.15872.


Для цитирования:


Маев И.В., Карлович Т.И., Бурмистров А.И., Чекмазов И.A., Андреев Д.Н., Решетняк В.И. Современные представления о роли torque teno virus (TTV) при заболеваниях печени. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2020;30(4):7-22. https://doi.org/10.22416/1382-4376-2020-30-4-7-22

For citation:


Maev I.V., Karlovich T.I., Burmistrov A.I., Chekmazov I.A., Andreev D.N., Reshetnyak V.I. Current Views of Torque Teno Virus (TTV) in Liver Diseases. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2020;30(4):7-22. (In Russ.) https://doi.org/10.22416/1382-4376-2020-30-4-7-22

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