Endoscopic Detection of Gastric Metastases in Skin Melanoma
M. Yu. Kabanov,
K. V. Sementsov,
D. B. Degterev,
M. Ya. Belikova, 
D. K. Savchenkov,
T. E. Koshelev,
A. K. Stechishina
D. K. Savchenkov,
T. E. Koshelev,
A. K. Stechishina https://doi.org/10.22416/1382-4376-2020-30-6-63-68
Abstract
Aim. A clinical description of disseminated skin melanoma with endoscopic observation of its pathognomonic pigmented metastases into the stomach.
Key points. A 66-yo patient was hospitalised with dyspnoea, general weakness, cough and suspected community-acquired pneumonia. The patient had a complex examination, including computed tomography, which revealed a presumed malignancy of the right lung with secondary changes in the chest and abdominal organs. Esophagogastroduodenoscopy (EGDS) visualised multiple pigmented spots and raised black plaques in cardia and the gastric body diagnosed as a metastasising melanoma in stomach. Endoscopic verification of the metastases confirmed the correct diagnosis of primary skin melanoma.
Conclusion. Metastatic melanoma of the gastrointestinal tract has non-specific symptoms and most often occurs during the dissemination process. Endoscopy should be used to correctly verify pigmented mucosal lesions, necessarily allowing for non-pigmented gastric neoplasms in patients with skin melanoma in history.
About the Authors
M. Yu. Kabanov
Mechnikov North-Western State Medical University; War Veterans’ Hospital
Russian Federation
Russian Federation
Maksim Yu. Kabanov — Dr. Sci. (Med.), Prof., Chair of General Surgery, Mechnikov North-Western State Medical University; Head of the War Veterans’ Hospital.
193079, St. Petersburg, Narodnaya str., 21, 2
K. V. Sementsov
Mechnikov North-Western State Medical University; War Veterans’ Hospital
Russian Federation
Russian Federation
Konstantin V. Sementsov — Cand. Sci. (Med.), Assoc. Prof., Chair of General Surgery, Mechnikov North-Western State Medical University; Deputy Head of the War Veterans’ Hospital.
193079, St. Petersburg, Narodnaya str., 21, 2
D. B. Degterev
War Veterans’ Hospital
Russian Federation
Russian Federation
Denis B. Degterev — Cand. Sci. (Med.), Head of the Endoscopy Unit
193079, St. Petersburg, Narodnaya str., 21, 2
M. Ya. Belikova
Mechnikov North-Western State Medical University; War Veterans’ Hospital
Russian Federation
Russian Federation
Maria Ya. Belikova — Cand. Sci. (Med.), Assoc. Prof., Chair of Radiation Diagnostics and Therapy, Mechnikov NorthWestern State Medical University; Head of the Computed Tomography Unit, War Veterans’ Hospital.
193079, St. Petersburg, Narodnaya str., 21, 2
D. K. Savchenkov
Mechnikov North-Western State Medical University; War Veterans’ Hospital
Russian Federation
Russian Federation
Dmitriy K. Savchenkov— Cand. Sci. (Med.), Research Assistant, Chair of General Surgery, Mechnikov North-Western State Medical University; Physician (endoscopy), Endoscopy Unit, War Veterans’ Hospital.
193079, St. Petersburg, Narodnaya str., 21, 2
T. E. Koshelev
Mechnikov North-Western State Medical University
Russian Federation
Russian Federation
Taras E. Koshelev — Cand. Sci. (Med.), Assoc. Prof., Chair of General Surgery
191015, St. Petersburg, Kirochnaya str., 41
A. K. Stechishina
Mechnikov North-Western State Medical University
Russian Federation
Russian Federation
Arina K. Stechishina — Graduate Student
191015, St. Petersburg, Kirochnaya str., 41
References
1. Michielin O., van Akkooi A.C.J., Ascierto P.A., Dummer R., Keilholz U.; ESMO Guidelines Committee. Cutaneous melanoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2019;30(12):1884–901. DOI: 10.1093/annonc/mdz411
2. Dasgupta T., Brasfield R. Metastatic melanoma. A clinicopathologic study. Cancer. 1964;17:1323–39. DOI: 10.1002/1097-0142(196410)17:10<1323::aidcncr2820171015>3.0.co;2-n
3. Pirogov S.S., Sokolov V.V., Kaprin A.D., Sokolov D.V., Volchenko N.N., Karova E.S. et al. Metastatic gastric lesion in skin melanoma: multimodal endoscopic diagnosis. Experimental and Clinical Gastroenterology. 2017;144(8):79–86 (In Russ.).
4. Augustyn A., de Leon E.D., Yopp A.C. Primary gastric melanoma: case report of a rare malignancy. Rare tumors. 2015;7(1):5683. DOI: 10.4081/rt.2015.5683
5. Blecker D., Abraham S., Furth E.E., Kochman M.L. Melanoma in the gastrointestinal tract. Am J Gastroenterol. 1999;94(12):3427–33. DOI: 10.1111/j.1572-0241.1999.01604.x
6. Genova P., Sorce M., Cabibi D., Genova G., Gebbia V., Galanti D., et al. Gastric and Rectal Metastases from Malignant Melanoma Presenting with Hypochromic Anemia and Treated with Immunotherapy. Case Rep Oncol Med. 2017;2017:2079068. DOI: 10.1155/2017/2079068. Erratum in: Case Rep Oncol Med. 2018;2018:3142394.
7. Issa H., Poovathumkadavil A.M., Almousa F., Al-Salem A.H. Metastatic Malignant Melanoma of the Small Intestines Diagnosed by Capsule Endoscopy. Gastroenterology Res. 2011;4(5):236–9. DOI: 10.4021/gr342w
8. Goral V., Ucmak F., Yildirim S., Barutcu S, Ileri S., Aslan I., Buyukbayram H. Malignant melanoma of the stomach presenting in a woman: a case report. J Med Case Rep. 2011;5:94. DOI: 10.1186/1752-1947-5-94
9. Farshad S., Keeney S., Halalau A., Ghaith G. A Case of Gastric Metastatic Melanoma 15 Years after the Initial Diagnosis of Cutaneous Melanoma. Case Rep Gastrointest Med. 2018;2018:7684964. DOI: 10.1155/2018/7684964
10. Sacks B.A., Joffe N., Antonioli D.A. Metastatic melanoma presenting clinically as multiple colonic polyps. Am J Roentgenol. 1977;129(3):511–3. DOI: 10.2214/ajr.129.3.511
Review
For citations:
Kabanov M.Yu., Sementsov K.V., Degterev D.B., Belikova M.Ya., Savchenkov D.K., Koshelev T.E., Stechishina A.K. Endoscopic Detection of Gastric Metastases in Skin Melanoma. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2020;30(6):63-68. (In Russ.) https://doi.org/10.22416/1382-4376-2020-30-6-63-68
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