Asymptomatic Barrett’s Oesophagus-Complicated Gastroesophageal Reflux Disease at Ineffective Antisecretory Therapy
https://doi.org/10.22416/1382-4376-2021-31-2-46-53
Abstract
Aim. A clinical description of gastroesophageal reflux disease (GERD) complicated by Barrett’s oesophagus (BO) at inadequate antisecretory therapy and the assessment of functional tests in control of conservative treatment.
Key points. A 63-yo patient with no complaints in a proton pump inhibitor (PPI) therapy was admitted for a follow-up examination for BO-complicated GERD using oesophagogastroduodenoscopy (OGDS) with biopsy, high-resolution oesophageal manometry and 24-h pH-impedance. Endoscopy revealed signs of BO (long segment C1M3), erosive reflux oesophagitis (grade B in Los Angeles classification). Non-contractile oesophagus in manometry. Antisecretory therapy was stated ineffective and subject to correction in 24-h pH-impedance.
Conclusion. Asymptomatic BO-complicated GERD patients comprise a special cohort. The main challenge to prevent progression into oesophageal adenocarcinoma is an adequate personalised patient management leveraging the modern diagnostic techniques, control of antisecretory treatment and its correction a situ.
About the Authors
E. V. Barkalova
Yevdokimov Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
Elena V. Barkalova — Research Assistant, Chair of Internal Disease Propaedeutics and Gastroenterology, Headof the Laboratory of Functional Methods in Gastroenterology
127473, Moscow, Delegatskaya str., 20, bld. 1
S. S. Pirogov
National Medical Research Radiology Centre
Russian Federation
Russian Federation
Sergey S. Pirogov — Dr. Sci. (Med.), Head of the Department of Endoscopy, Herzen Moscow Oncology Research Centre — Branch of the National Medical Research Radiology Centre
125284, Moscow, Vtoroy Botkinskiy pr., 3
D. N. Andreev
Yevdokimov Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
Dmitriy N. Andreev — Cand. Sci. (Med.), Research Assistant, Chair of Internal Disease Propaedeutics and Gastroenterology, Researcher, Laboratory of Functional Methods in Gastroenterology
127473, Moscow, Delegatskaya str., 20, bld. 1
M. A. Ovsepyan
Yevdokimov Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
Maria A. Ovsepyan — Senior Laboratory Assistant, Chair of Internal Disease Propaedeutics and Gastroenterology
127473, Moscow, Delegatskaya str., 20, bld. 1
I. V. Maev
Yevdokimov Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
Igor V. Maev— Dr. Sci. (Med.), Full Member of the Russian Academy of Sciences, Prof., Head of the Chair of Internal Disease Propaedeutics and Gastroenterology
127473, Moscow, Delegatskaya str., 20, bld. 1
A. D. Kaprin
National Medical Research Radiology Centre
Russian Federation
Russian Federation
Andrey D. Kaprin — Dr. Sci. (Med.), Full Member of the Russian Academy of Sciences, Director, National Medical Research Radiology Centre.
249031, Obninsk, Marshala Zhukova str., 10
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For citations:
Barkalova E.V., Pirogov S.S., Andreev D.N., Ovsepyan M.A., Maev I.V., Kaprin A.D. Asymptomatic Barrett’s Oesophagus-Complicated Gastroesophageal Reflux Disease at Ineffective Antisecretory Therapy. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2021;31(2):46-53. (In Russ.) https://doi.org/10.22416/1382-4376-2021-31-2-46-53
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