Phenotypic and genotypic features of the full-term newborns with delayed conjugation jaundices in relation to gender of the child
Abstract
Aim of investigation. To detect phenotypic and genotypic features of the full-term newborns with delayed conjugation jaundice in relation to gender of the patient.
Material and methods. The group of full-term children (n=251) with delayed conjugation jaundice was investigated, that have been divided in two subgroups according to gender. All patients underwent complex clinical and laboratory, instrumental and immunologic investigation. Features of pregnancy and delivery course, weight and height scores and children disease spectrum, blood groups and Rhesus factor were investigated.
Results. It was known, that prevailing genotypic changes in boys – increased proportion of 0 (I) groups and decreased proportion of A (II) blood group, as well as increase of proportion of phenotypes 0 Rh + and decrease of A Rh + in boys prevail in comparison to girls and control group, while in girls environmental factors (complicated course of pregnancy and delivery) have more pronounced effect. Boys and girls differ by disease spectrum. Assessment of these diseases shows, that state of girls was more severe.
Conclusions. The original study allows to conclude, that children with delayed conjugation jaundice in neonatal period belong to risk group for development of complications at action of harmful external factors over the liver.
About the Authors
O. K. Botvin'yev
State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
A. I. Kolotilina
State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
I. N. Razumovskaya
State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
A. V. Yeremeyeva
State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
References
1. Акушерство: Национальное руководство / Под ред. Э.К. Айламазяна, В.И. Кулакова, В.Е. Радзинского, Г.М. Савельевой. – М.: ГЭОТАР Медиа, 2007. – 1200 с.
2. Амзаракова Т.Ф., Душинина А.К. Выявление факторов риска затяжного течения неонатальных желтух // В мире научных открытий. – 2010. – № 4 (10), ч. 9. – С. 95–97.
3. Баканов М.И. Биохимия печени: физиология и патология // Вопр. диагностики в педиатрии. – 2010. – Т. 2, № 2. – С. 12–20.
4. Ботвиньев О.К. Системный анализ связей между фенотипическими признаками и состоянием здоровья детей: Автореф. дис. … д-ра мед. наук. – М., 1984. –43 с.
5. Ботвиньев О.К., Курбатова О.Л., Алтухов Ю.П. Популяционно-генетический подход к проблеме неспецифической биологической устойчивости человеческого организма: Сообщение 2: Клиническая характеристика врожденных аномалий и генетическая структура больных детей с учетом их веса и длины тела при рождении // Генетика. – 1980. – Т. 16, № 10. – С. 1884–1894.
6. Бочков Н.П. Клиническая генетика. – М.: ГЭОТАР Медиа, 2002. – С. 202–206.
7. Володин Н.Н., Дегтярева А.В., Дегтярев Д.Н. Основные причины желтух у новорожденных детей и принципы их дифференциальной диагностики // Рос. вестн. перинатологии и педиатрии. – 2004. – № 5. – С. 18–23.
8. Жирмунский А.В., Кузьмин В.И. Критические уровни в процессах развития биологических систем. – М.: Наука, 1982. – 178 с.
9. Салмова В.С. Пигментные гепатозы // Лекции по педиатрии. – Т. 3. Гастроэнтерология / Под ред. В.Ф. Демина, С.О. Ключниковой, Л.Н. Цветковой, Ю.Г. Мухиной. – М.: Изд. РГМУ, 2003. – С. 216–225.
10. Таболин В.А. Билирубиновый обмен и желтухи новорожденных. – М.: Медицина, 1967. – 226 с.
11. Яцык Г.В., Беляева И.А., Одинаева Н.Д. Желтухи новорожденных. – М.: «АдамантЪ», 2008. – 32 с.
12. Jon F. Watchko, Z. Lin. Complex multifactorial nature of significant hyperbilirubinemia in neonates // Pediatrica. – 2009. – Vol. 124, N 5. – P. 868–875.
13. Kawade N., Onishi S. The prenatal and postnatal development of UDP-glucuronyltransferaze activity towards bilirubin and the effect of premature on this activity in the human liver // Biochem. J. – 1981. – Vol. 196. – P. 257–260.
14. Shogo J. Miyagi, Abby C. Collier. The development of UDP-glucuronosyltransferases 1A1 and 1A6 in the pediatric liver // Drug Metab. Dispos. – 2011. – Vol. 39, N 5. – P. 912–919.
Review
For citations:
Botvin'yev O.K., Kolotilina A.I., Razumovskaya I.N., Yeremeyeva A.V. Phenotypic and genotypic features of the full-term newborns with delayed conjugation jaundices in relation to gender of the child. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2013;23(6):29-34. (In Russ.)
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