Diseases of the stomach and duodenum at chronic obstructive pulmonary disease: pathogenesis, clinical presentation and diagnostics
Abstract
Aim of investigation. To analyze clinical, diagnostic features and some mechanisms of development of the stomach and duodenum lesions on a background of chronic obstructive pulmonary disease (COPD).
Materials and methods. One hundred of patients with chronic obstructive disease of lungs were investigated. Clinical, endoscopic, morphological, roentgenological, immunologic methods, pulse-oximetry were applied. Results. Higher smoking index (38,81 packs /years) was found at increase of COPD severity stage and aggravation of inflammatory and atrophic changes of gastric and duodenal mucosa (34,18 packs /years). Erosive and ulcerative lesions of this area were significantly more frequently found at increase of respiratory failure (RF): in 27,3% of patients – at the I stage of RF, in 41,5% – at the II stage of RF (р<0,05). In turn, the stage of RF correlated to smoking index (r=0,535). Conclusions. Interrelation between severity of lesions of the stomach and duodenum in patients with chronic obstructive pulmonary disease, smoking index and baseline therapy was revealed. The significant role of disorders of immune, autoimmune and cytokine homeostasis in development of these lesions is demonstrated.>< 0,05). In turn, the stage of RF correlated to smoking index (r=0,535).
Conclusions. Interrelation between severity of lesions of the stomach and duodenum in patients with chronic obstructive pulmonary disease, smoking index and baseline therapy was revealed. The significant role of disorders of immune, autoimmune and cytokine homeostasis in development of these lesions is demonstrated.
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Review
For citations:
Kozlova I.V., Chumak Ye.P. Diseases of the stomach and duodenum at chronic obstructive pulmonary disease: pathogenesis, clinical presentation and diagnostics. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2008;18(6):75-80. (In Russ.)
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